SPACELINE Current Awareness List

NASA Spaceline Current Awareness List #1,168 3 October 2025 (Space Life Science Research Results)

By Keith Cowing
Status Report
NASA
October 17, 2025
Filed under , , , ,
NASA Spaceline Current Awareness List #1,168  3 October 2025 (Space Life Science Research Results)
space life science – Grok via astrobiology.com

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

  1. Goswami N, Blaber AP, Valenti G, Hinghofer-Szalkay H, Evans J, Bailey DM, Vernikos J, Choukér A, Green DA, White O, van Loon JJWA, Convertino VA.Gravity, microgravity, and artificial gravity: Physiological effects, implementation, and applications.Physiol Rev. 2025 Sep 29. Review. Online ahead of print.Note: This article may be obtained online without charge.

    Journal Impact Factor: 28.7

    Funding: J. Vernikos is affiliated with Life Sciences at NASA Headquarters.
  2. Gill AR, Miller TK, Wijeweera S, Herrero E, Massa GD, Mortimer JC, Webb AAR, Millar AH, Gilliham M.Turbocharging fundamental science translation through controlled environment agriculture.Trends Plant Sci. 2025 Sep 30. Online ahead of print.Note: This article may be obtained online without charge.

    Journal Impact Factor: 20.8

    Funding: G.D. Massa is affiliated with NASA Kennedy Space Center.
  3. Sierra MA, Ryon K, Arikatla MR, Elshafey R, Bhaskar H, Proszynski J, Bhattacharya C, Shaaban H, Danko DC, Ambrose P, Spaulding SA, Zambrano MM, Consortium TMD, Mason CE.The microbe directory: A centralized database for biological interpretation of microbiome data.Database (Oxford). 2025 Sep 24;baaf060.PI: C.E. MasonNote: This article may be obtained online without charge.

    Journal Impact Factor: 3.6

    Funding: “C.E.M. was supported by the National Institutes of Health (U01DA053941, U54AG089334, R01AI151059), NASA (80NSSC24K0728, 80NSSC24K1052), and the WorldQuant Foundation.”
  4. Lin Y-Y, Warren E, Macklin BL, Ramirez L, Gerecht S.Endothelial-pericyte interactions regulate angiogenesis via VEGFR2 signaling during retinal development and disease.Invest Ophthalmol Vis Sci. 2025 Sep;66(12):45.PI: S. GerechtNote: This article may be obtained online without charge.

    Journal Impact Factor: 4.7

    Funding: “Taiwan-Whiting School of Engineering/Johns Hopkins University Fellowships program (YL, partially funded); Department of Defense (DoD) through the National Defense Science & Engineering Graduate (NDSEG) Fellowship Program (EW); NRSA F31 predoctoral fellowship F31HL143972 from NHLBI (BLM); Duke Cancer Institute as part of the P30 Cancer Center Support Grant (Grant ID: P30 CA014236); Air Force Office of Scientific Research grant FA9550-20-1-0356 (SG); Translational Research Institute through NASA Cooperative Agreement NNX16AO69A, grants RAD0102 and SNT0101 (SG); and National Eye Institute grant EY035853 (SG).”

Other papers of interest:

  1. Balali P, Luchitskaya E, Hossein A, Abdessater E, Faoro V, Debeir O, Tank J, Caiani EG, van de Borne P, Migeotte PF, Rabineau J.Evidence of effective cardiovascular countermeasures during spaceflights: Insights from wearable monitoring.npj Microgravity. 2025 Sep 30;11(1):68.Note: ISS results. From the abstract: “In this paper, we present the results from 17 cosmonauts (16 men, 1 woman) with (median [first quartile; third quartile]): age of 44 years, body weight of 83 kg, and body height of 178 cm at the time of their pre-flight record. They stayed 185 days aboard the ISS, with 13 (1 woman) of them assigned to a 6-month mission and 4 of them assigned to a 1-year mission. During their time in space, the cosmonauts followed their normal schedule, including countermeasures based on physical exercise. Informed consent was obtained from each participant prior to starting the study. Additionally, they were made aware of their right to withdraw from the study at any time.” This article may be obtained online without charge.
  2. Limper U, Jordan J.Neck-vein thrombosis during spaceflight.Br J Clin Pharmacol. 2025 Oct 2. Review. Online ahead of print.Note: This article may be obtained online without charge.
  3. Cai L, Liu Y, Niu H, Zheng W, Wang H, Lv H, Ren P, Wang Z.AgGAN: Anatomy-guided generative adversarial network to synthesize arterial spin labeling images for cerebral blood flow measurement under simulated microgravity.Med Image Anal. 2026 Jan;107(Pt A):103817.Note: Head-down tilt bedrest study.
  4. Berggren Å, Jensen AB, Copplestone D, Guidetti R, Heer M, Pittia P.Insects in bioregenerative life support systems: Unlocking their role in space sustainability.Front Physiol. 2025 Sep 9;16:1621099. Review.Note: This article is part of Research Topic “Innovations in Tools and Methods for Life Sciences Research in Space” (https://www.frontiersin.org/research-topics/68978/innovations-in-tools-and-methods-for-life-sciences-research-in-space). The Research Topic also includes articles from previous Current Awareness Lists #1,155 https://doi.org/10.3389/fphys.2025.1599005, #1,156 https://doi.org/10.3389/fphys.2025.1622401, and #1,165 https://doi.org/10.3389/fphys.2025.1628696. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
  5. Blondelli F, Toto E, Botti S, Bonfigli F, Laurenzi S, Santonicola MG.Polyimide/graphene nanocomposites for space applications: Potential antibacterial coatings for human exploration missions.Acta Astronaut. 2025 Sep 25. Online ahead of print.Note: From the abstract: “This work focuses on the development and characterization of nanocomposite coatings designed for long-term space missions, aiming to prevent bacterial adhesion while maintaining optimal physical and chemical properties. Preventing biofilm formation and bacteria proliferation on surfaces is a crucial aspect in space, since they pose serious risks to astronaut health, spacecraft durability, and mission success.”
  6. Capri M, Montano N, Piccirillo S, Narici M, Ferranti F, Maccarrone M.Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system.npj Microgravity. 2025 Sep 26;11(1):66. Review.Note: This article may be obtained online without charge.
  7. Ding X, Pang Y, Zhang B, Zhao L, Niu X, Xu D.Dose-specific lncRNA-mRNA networks modulate DNA damage and immune responses in CD4+ T cells under simulated space UVC irradiation.Life Sci Space Res. 2025 Sep 28. Online ahead of print.
  8. Lee R, Rayhun A, Kim JK, Meydan C, Beheshti A, Sporn K, Kumar R, Calixte J, McNerney MW, Shah J, Waisberg E, Ong J, Mason C.Genomic analysis of cardiovascular diseases utilizing space omics and medical atlas.Genes (Basel). 2025 Aug 25;16(9):996.Note: This article is part of Section “Molecular Genetics and Genomics” (https://www.mdpi.com/journal/genes/sections/molecular_genetics) and may be obtained online without charge.
  9. Haq S, Hájek J, Barták M.From Antarctic regolith to lunar greenhouses: Mechanistic insights into Brassica rapa photosystem II dynamics for sustainable space agriculture.Life Sci Space Res. 2025 Sep 25. Online ahead of print.
  10. Phetruen T, Thongdechsri S, Khongthongdam M, Channumsin S, Meemon K, Chanarat S.Effects of simulated microgravity on biological features and virulence of the fungal pathogen Cryptococcus neoformans.Appl Environ Microbiol. 2025 Sep 30;e0143525.Note: A 3D clinostat was used in this study to simulate microgravity. This article may be obtained online without charge.
  11. Plotnikov E, Artamonov A.An umbrella review and meta-analysis: Antimicrobial properties of metal nanoparticles as alternative anti-infective agents for space missions.Acta Astronaut. 2025 Sep 29. Online ahead of print.
  12. Pulvirenti E, Diteesawat RS, Pavei G, Natalucci V, Hauser H, Minetti A, Rossiter J.A resistive soft robotic exosuit for dynamic body loading in hypogravity.Adv Sci (Weinh). 2025 Sep 30;e06057. Online ahead of print.Note: This article may be obtained online without charge.
  13. Vale JS, Pimenta SM..Obstructive sleep apnea syndrome: Aeronautical medical assessment.Rev Bras Med Trab. 2025 Jul-Sep;23(3):e20241326.Note: This article may be obtained online without charge.
  14. Hou S, Wang Z, Zhu Y, Liu H, Feng J.Positive effects and mechanisms of simulated lunar low-magnetic environment on earthworm-improved lunar soil simulant as a cultivation substrate.Acta Astronaut. 2025 Sep 26. Online ahead of print.
  15. Parousis-Paraskevas O, Gkikoudi A, Al-Qaaod A, Vasilopoulos SN, Manda G, Beinke C, Haghdoost S, Terzoudi GI, Krasniqi F, Georgakilas AG.Combined radiations: Biological effects of mixed exposures across the radiation spectrum.Biomolecules. 2025 Sep 5;15(9):1282. Review.Note: This article is part of Section “Molecular Biology” (https://www.mdpi.com/journal/biomolecules/sections/bio_molecular_biology) and may be obtained online without charge.
  16. Wang Y, Goonetilleke RS, Lin RF, Luximon A, Luximon Y.Proprioception and vision relationship in aimed movement with restricted and reversed vision.Appl Ergon. 2026 Jan;130:104649.Note: From the abstract: “Human movement relies on visual and proprioceptive inputs, and the movement can be hampered when either input provides limited or distorted information, as in robotic surgery, virtual reality, or spaceflight. This study examines how proprioception influences performance in aimed movement tasks under restricted and inverted visual conditions.”
  17. Van Puyvelde M, van den Berg NH, Stas L, Savieri P, Corlùy H, Van Cutsem J, Neyt X, Simonelli G, Pattyn N.Beyond the lab coat: Methodological challenges in space life sciences.Front Physiol. 2025 Oct 3;16:1663701.Note: This article is part of Research Topic “Innovations in Tools and Methods for Life Sciences Research in Space” (https://www.frontiersin.org/research-topics/68978/innovations-in-tools-and-methods-for-life-sciences-research-in-space). The Research Topic also includes articles from previous Current Awareness Lists #1,155 https://doi.org/10.3389/fphys.2025.1599005, #1,156 https://doi.org/10.3389/fphys.2025.1622401, and #1,165 https://doi.org/10.3389/fphys.2025.1628696. This article may be obtained online without charge.

astrobiology, space biology, space medicine, microgravity, ISS,

Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻