NASA Spaceline Current Awareness List #1,145 18 April 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Sandhur BS, Ong J, Sampige R, Lee R, Memon H, Panzo N, Kadipasaoglu CM, Guo Y, Soares B, Osteicoechea D, Waisberg E, Suh A, Nguyen T, Masalkhi M, Sarker P, Zaman N, Tavakkoli A, Berdahl J, Chévez-Barrios P, Mader TH, Gibson CR, Lee AG.The case for anterior segment optical coherence tomography (AS-OCT) for the International Space Station and future planetary spaceflight: Clinical relevance and technical implementation.Life Sci Space Res. 2025 Aug;46:74-85.Note: This article is an opinion/position paper.
   
   Journal Impact Factor: 2.9
   
   Funding: C.R. Gibson is affiliated with NASA Johnson Space Center.
2. Rahill KM, Mulavara AP, George K, Gore BF, Whitmire AM.Increasing fidelity in lunar and Martian analogs for behavioral health and performance research.Front Space Technol. 2025 Apr 1;6:1505823.Note: From the abstract: “As the National Aeronautics and Space Administration (NASA), international space agencies, and commercial spaceflight programs set their sights on missions to the Moon and Mars, understanding the impact of spaceflight on astronauts’ health and performance becomes increasingly important. High-fidelity ground-based and space-based simulations of hazards induced by these missions can be used to conduct research that will help mitigate potential adverse outcomes in behavioral health and performance. In this review, current classifications of NASA’s research analogs are discussed, along with their strengths and limitations for effectively assessing risk to Moon- and Mars-bound astronauts’ behavioral health and performance.” This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “This study was funded by NASA’s Human Research Program.”
3. Akter Tani T, Scouten A, Ortiz E, McLean RJC, Tešić J.Automated corrosion identification in metal imagery: Traditional vs. deep learning.Advances in Visual Computing. 2025 Jan.PI: RJC McLeanNote: This article is a conference paper published in the peer-reviewed journal Springer Nature Journal Advances in Visual Computing. From the abstract: “Microbial-induced corrosion (MIC) poses a significant challenge in various industrial settings, including space and ground flight applications. Identifying and mitigating corrosion in metallic surfaces is crucial for ensuring the structural integrity and longevity of engineering systems. Segmenting MIC allows for early detection and proactive repair, which improves safety and cost efficiency in environments such as the International Space Station. This study presents a novel baseline algorithm called CLF (clustering using local features) for MIC segmentation based on traditional Non-Deep Learning techniques.”
   
   Journal Impact Factor: 2.4
   
   Funding: “This work has been partially supported by the NSF # 2224449 grant, RJCM is supported by NASA grant 80NSSC22K1361, and the Texas State University Research Enhancement Program grant.”
4. Du Le VN, Fronckowiak S, Badolato E.A cost-effective method for the spectral calibration of photoplethysmography pulses: The optimal wavelengths for heart rate monitoring.Sensors. 2025 Apr 5;25(7):2311.Note: This article is part of Special Issue “Next-Generation Haptic Technologies: Materials, Mechanisms, and Applications” (https://www.mdpi.com/journal/sensors/special_issues/32P5827OD5) and may be obtained online without charge.
   
   Journal Impact Factor: 3.4
   
   Funding: “This work is partially funded by the NASA EPSCoR Program.”

Other papers of interest:

1. Antonsen E.Chapter 14 – Risk and systems knowledge in human spaceflight.In: Schmidt MA, Legato MJ, eds. Building a Space-Faring Civilization. Academic Press, 2025. p. 181-94.
2. Blunier S, Athanasopoulos D, Dittmar C, Thoresen F, Cowley A, Fogtman A.Regolith-based lunar habitat for astronaut radiation protection and organ dose assessment.Planetary Space Sci. 2025 Jul;261:106116.
3. Bourdakou MM, Loizidou EM, Spyrou GM.Plasticity of gene expression in spaceflight and postflight in relation to cardiovascular disease: Mechanisms and candidate repurposed drugs.Proteomics. 2025 Apr 14;e202400241. Online ahead of print.Note: This article may be obtained online without charge.
4. Corbally CJ.Chapter 21 – Harnessing neuroplasticity’s features for civilian spaceflight through remediation and treatment.In: Schmidt MA, Legato MJ, eds. Building a Space-Faring Civilization. Academic Press, 2025. p. 303-9.
5. Franco N, Babocs D, Christiansen R, Drudi LM, Rajput S.Chapter 27 – Vascular surgery in spaceflight.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press, 2025. p. 435-44.
6. Wuyts FL, Deblieck C, Vandevoorde C, Durante M.Brains in space: Impact of microgravity and cosmic radiation on the CNS during space exploration.Nat Rev Neurosci. 2025 Apr 17. Review. Online ahead of print.
7. Xiong Y, Guo J, Yu W, Zeng D, Song C, Zhou L, Anatolyevna NL, Baranenko D, Xiao D, Zhou Y, Lu W.Molecular mechanism of microgravity-induced intestinal flora dysbiosis on the abnormalities of liver and brain metabolism.Int J Mol Sci. 2025 Mar 27;26(7):3094.Note: A 3D clinostat was used in this study. This article may be obtained online without charge.
8. Lee R, Ong J, Waisberg E, Fanning SL, Lee AG.Spaceflight associated dry eye syndrome (SADES): Outflow biophysics and infection risk.J Space Saf Eng. 2025 Apr 10. Online ahead of print.
9. Lowery C, Heft N, Beger S, Stewart LH.Chapter 13 – Emergency medicine in spaceflight.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space. Academic Press, 2025. p. 179-206.
10. Przybyla C, Babut R, Laganier H, Dutto G, Mansuy E, Elie S, Lallement S, Cavalie I, Darias MJ, Hermet S, Balcon N, Perrot Y, Adam-Guillermin C.Effects of neutron exposure on the embryonic development of European sea bass (Dicentrarchus labrax), a candidate fish species for space aquaculture: Simulated conditions on the ISS and during a lunar mission.Front Space Technol. 2025 Apr 16;6:1571592.Note: This article may be obtained online without charge.
11. Shestoperov AI, Ivchenko AV, Fomina EV.Human locomotion monitoring in spaceflight: Retrospective nonparametric changepoint detection methods.Microgravity Sci Technol. 2025 Mar 26;37(2):19.
12. Babocs D, Korrapati K, Lytle C, Gloviczki ML, Oderich GS, Melin MM, Christiansen R.Wound-healing and onboard care during long-duration human deep space exploration from a surgical perspective through the lens of a scoping review.J Vasc Surg Venous Lymphat Disord. 2025 Apr 15. Review.Note: This article may be obtained online without charge.
13. Wostyn P, Nedergaard M.Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS).Life Sci Space Res. 2025 Apr 17. Online ahead of print.
14. Duo D, Zhu J, Wang M, Wang X, Qu N, Li X.Long-term exposure to high-altitude hypoxic environments reduces blood pressure by inhibiting the renin-angiotensin system in rats.Front Physiol. 2025 Apr 15;16:1565147.Note: This article may be obtained online without charge.
15. Komatsu S, Misaki H, Zhu W, Yamaguchi H, Hitachi K, Tsuchida K, Higashitani A.The growth of soybean (Glycine max) under salt stress is modulated in simulated microgravity conditions.Cells. 2025 Apr 3;14(7):541.Note: A 3D clinostat was used to simulate microgravity. This article is part of Section “Cell Methods” (https://www.mdpi.com/journal/cells/sections/Cell_Methods) and may be obtained online without charge.
16. Krobthong S, Yingchutrakul Y, Butkinaree C, Tantapakul C, Moung-ngam P, Boonhaijaroen N, Aonbangkhen C, Channumsin S, Tulyananda T.RD22 as a potential rice variety for space exploration: Investigating the impact of a clinostat-simulated microgravity on seed germination across commercial rice varieties.Acta Astronautica. 2025 Apr 4. Online ahead of print.Note: A 3D clinostat was used to simulate microgravity.
17. Pearce N.The Challenger disaster: NASA, public health, and the precautionary principle.Am J Public Health. 2025 Mar 12;115(4):448-50.
18. Zhou X, Li S, Wang L, Wang J, Zhang P, Chen X.The emerging role of exercise preconditioning in preventing skeletal muscle atrophy.Front Physiol. 2025 Mar 25;16:1559594.Note: This article may be obtained online without charge.

Astrobiology, space biology, space medicine, microgravity, space station,