NASA Spaceline Current Awareness List #1,128 13 December 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Allred AR, Austin CR, Klausing L, Boggess N, Clark TK.Human perception of self-motion and orientation during galvanic vestibular stimulation and physical motion.PLoS Comput. Biol. 2024 Nov 18;20(11):e1012601.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this publication
   
   Funding: “This work was supported by a NASA Space Technology Graduate Research Opportunities Award (Grant No. 80NSSC20K1202 to ARA), which paid the salary of ARA. This project has been funded in whole or in part with Federal funds from the National Aeronautics and Space Administration (Contract No. 80NSSC21C0253 to TKC), which paid the salary of TKC, CRA, and LK.”
2. Leon Parada K, Luderer U.Ovarian issues in human spaceflight.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space. Academic Press, 2025. p. 351-80.PI: U. LudererNote: This article may be obtained online without charge.
   
   Funding: NASA grant #80NSSC19K1620
3. Nemec-Bakk AS, Sridharan V, Willey JS, Koturbash I, Williams DK, Chesal M, Patel CM, Borg AM, Reno K, Gifford G, Newhauser W, Williams J, Chancellor JC, Boerma M.Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.Life Sci Space Res. 2024 Dec 6. Online ahead of print.PI: A.S. Nemec-BakkJournal Impact Factor: 2.9
   
   Funding: “This research was funded by NASA, grant number 80JSC019N001-HHCBPSR, the Translational Research Institute for Space Health (TRISH), grant number P0702, and NIGMS, grant number P20 GM109005. …”
4. Skiles CM, Boyd G, Gouw A, Robbins E, Minchev K, Ryder J, Ploutz-Snyder L, Trappe TA, Trappe S.Myonuclear and satellite cell content of the vastus lateralis and soleus with 70 days of simulated microgravity and the NASA SPRINT exercise program.J Appl Physiol (1985). 2024 Dec 10. Online ahead of print.PI: L. Ploutz-SnyderNote: Head-down tilt bedrest study.
   
   Journal Impact Factor: 3.3
   
   Funding: “UL1TR000071/HHS | NIH | National Center for Advancing Translational Sciences (NCATS); NNX11AJ62G/National Aeronautics and Space Administration (NASA).”
5. Strohm AO, Oldfield S, Hernady E, Johnston CJ, Marples B, O’Banion MK, Majewska AK.Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice.Brain Behav Immun – Health. 2025 Feb;43:100911.PI: M.K. O’BanionJournal Impact Factor: 3.7
   
   Funding: “This work was supported by NINDS R01 NS114480 (AKM), T32ES007026 (AOS), NASA 80NSSC21K0542 (MKO), a Joan Wright Goodman award from the University of Rochester (AOS), and an Ernest J. Del Monte Institute for Neuroscience Pilot Grant (MKO). Additionally, this work utilized the University of Rochester Wilmot Cancer Institute Imaging and Radiation Shared Resource and S10 NIH grant S100D021548 (BM).”
6. López-Pozo M, Adams WW, McNamara M, Demmig-Adams B.A preharvest finishing procedure for Lemna to produce high levels of zeaxanthin that is retained post-high-light exposure.Future Foods. 2024 Dec;10:100517.PI: B. Demmig-AdamsNote: From the abstract: “Development of a productive, nutritious, and low-input food source is needed for humanity’s expanding population on Earth and for long-duration crewed space missions. The exceptionally protein- and micronutrient-rich members of the aquatic plant family Lemnaceae are uniquely suited for both purposes. Here, we introduce a protocol to accumulate large quantities of the carotenoid zeaxanthin that are retained post-high-light exposure.”
   
   Journal Impact Factor: 7.2
   
   Funding: “This work was supported by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A and the University of Colorado.”
7. Levin DR, McIntyre L, Steller JG, Nelson A, Zahner C, Anderson A, Parmar P, Hilmers DC.Predicting exploration crew medical officer training needs: Applying evidence-based predictive analytics to space medicine training.Wilderness Environ Med. 2024 Dec 10;10806032241292535. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 1.4
   
   Funding: L. McIntyre is affiliated with NASA Glenn Research Center.

Other papers of interest:

1. Ceniza-Bordallo G, Zimmermann E, Vigouroux M, Niburski K, Fortin M, Ouellet J, Cata JP, Ingelmo PM.Low back pain during and after spaceflight: A systematic review with meta-analysis.J Pain Res. 2024 Dec 6;17:4103-39. Review.Note: This article may be obtained online without charge.
2. Chung M, Lee PHU.Challenges of the musculoskeletal system in space.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press, 2025. p. 335-49.
3. Patel SR, Nakada SY.Urolithiasis risk in spaceflight.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space. Academic Press, 2025. p. 61-71.
4. Scheinkman R, Janmohamed SR, Ginsburg S, Houk G, Gwillim E.Lunar dust dermatologic considerations for NASA’s Artemis program and the Gateway Space Station: A narrative review.Arch Dermatol Res. 2024 Dec 6;317(1):77.
5. Tian L, Ren J, Luo Y, Li Y, Guo W, Zhang B, Pan Y.Potential health risks of hypomagnetic field for crewed deep-space explorations.Natl Sci Rev. 2024 Dec;11(12):nwae395.Note: This article is a perspective and may be obtained online without charge.
6. Semenov YS, Popova JA, Luzhnov PV, Demin AV, Moreva TI, Kriushev ES, Nichiporuk IA, Dyachenko AI.Negative pressure breathing: The response of human respiration and circulation to different levels of rarefaction during inspiration.Front Physiol. 2024 Nov 26;15:1443349.Note: This article may be obtained online without charge.
7. Wang Z, Xie H, Chien JH.The ground reaction force pattern during walking under vestibular-demanding task with/without mastoid vibration: Implication for future sensorimotor training in astronauts.Front Physiol. 2024 Nov 19;15:1325513.Note: This article is part of Research Topic “Aerospace Health and Safety: Today and the Future, Volume II” (https://www.frontiersin.org/research-topics/50619/aerospace-health-and-safety-today-and-the-future-volume-ii/overview). The Research Topic also includes articles from previous Current Awareness Lists #1,085 https://doi.org/10.3389/fphys.2023.1298672. This article may be obtained online without charge.
8. Yin X, Grimm DAP, Zhou S, Pisors J, Yang Teo AZ, Lijenstolpe M, Doost EZ, Cooke NJ, Gorman JC.Observing resilient performance in space-based teaming mission using digital technologies.Appl Ergon. 2025 Apr;124:104409.Note: From the abstract: “Space-based teaming requires coordination across human operators using old (e.g., existing communication networks) and new (e.g., AI and robotic teammates) digital technologies (DTs) across great distances. Hence, methods are needed to observe resilience across multiple layers of coordination comprising DT-enabled space missions. This presented study simulates high-stakes scenarios to measure constructs like relaxation time, information entropy, and average mutual information (AMI) to evaluate team responses to perturbations.”
9. Russomano T, Rehnberg L, Pletser V, dos Santos MA, Herbert J.Clinical emergencies in space: Challenges, achievements, and future trends.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space. Academic Press, 2025. p. 251-71.
10. Zhang W, Chen N, Yuan J, Xu K, Lu L, Tong T, Liu Q, He Z, Zhang S, Yang J, Feng Y, Fan Z, Chen J, Yin H, Xiao K.Initial attempt: Design and application of microorganism-material interaction test on on-orbit space microgravity conditions.Acta Astronaut. 2024 Dec 6. Online ahead of print.
11. Strauch L, von der Wiesche M, Noppe A, Mulder E, Rieger I, Aeschbach D, Elmenhorst EM.Simulating microgravity with 60 days of 6 degree head-down tilt bedrest compromises sleep.npj Microgravity. 2024 Dec 5;10:109.Note: Head-down tilt bedrest study. This article may be obtained online without charge.
12. Anderson A, Theophanous RG.Point-of-care ultrasound use in austere environments: A scoping review.PLoS One. 2024 Dec 5;19(12):e0312017. Review.Note: From the introduction: “Point-of-care ultrasound use (POCUS) in austere environments is an exciting and developing topic, especially with rapid improvements in technology and miniaturization of POCUS over the past 15-20 years. Austere environments can be defined as locations that are outside of the standard hospital or clinic setting, sometimes with extreme temperatures, remote locations, or unique settings such as in deserts or outer space.” This article may be obtained online without charge.
13. Marcos-Lorenzo D, Lysandrou C, Sudres L, Gil-Martinez A, Swanenburg J, Clark JE, Green DA.50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper-buoyancy floatation versus 15 min sitting upright.Exp Physiol. 2024 Dec 4.Note: From the abstract: “Microgravity is associated with stature increases, back pain and post-flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness (VS), and back pain induced by 4 h hyper-buoyancy floatation (HBF) unloading.” This article may be obtained online without charge.

Astrobiology, space medicine, space biology, microgravity,