NASA Spaceline Current Awareness List #1,127 6 December 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Kumar K, Angdisen J, Ma J, Datta K, Fornace AJ Jr, Suman S.Simulated galactic cosmic radiation exposure-induced mammary tumorigenesis in Apc^Min/+ mice coincides with activation of ER α-ERRα-SPP1 signaling axis.Cancers. 2024 Nov 26;16(23):3954.PIs: A.J. Fornace Jr, S. SumanNote: This article is part of Special Issue “Radiation Exposure, Inflammation and Cancers” (https://www.mdpi.com/journal/cancers/special_issues/33Q81IUBU9). The Special Issue also includes an article from previous Current Awareness List #1,119 https://doi.org/10.3390/cancers16193392. Additional articles will be forthcoming and may be found in the Special Issue. This article may be obtained online without charge.
   
   Journal Impact Factor: 4.5
   
   Funding: “This research was funded by the National Aeronautics and Space Administration (NASA), grant number 80NSSC19K1649 and 80NSSC24K0287.”
2. Hameed A, McDonagh F, Sengupta P, Miliotis G, Sivabalan SKM, Szydlowski L, Simpson A, Singh NK, Rekha PD, Raman K, Venkateswaran K.Neobacillus driksii sp. nov. isolated from a Mars 2020 spacecraft assembly facility and genomic potential for lasso peptide production in Neobacillus.Microbiol Spectr. 2024 Nov 29;e0137624. Online ahead of print.Note: From the abstract: “This study highlights the unique metabolic capabilities of N. driksii, underscoring their potential in antimicrobial research and biotechnology.” This article may be obtained online without charge.
   
   Journal Impact Factor: 3.7
   
   Funding: “…Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with National Aeronautics and Space Administration. This research was funded by the JPL Mars Program award to KV in 2016. …”
3. Ribeiro Rodrigues V, Pratt RA, Stephens CL, Alexander DJ, Napoli NJ.Work of breathing for aviators: A missing link in human performance.Life (Basel). 2024 Oct 28;14(11):1388.Note: This article is part of Section “Physiology and Pathology” (https://www.mdpi.com/journal/life/sections/Physiology_and_Pathology) and may be obtained online without charge.
   
   Journal Impact Factor: 3.2
   
   Funding: “This research was funded by NASA Langley Research Center, NASA System-Wide Safety Project, and San Jose State University Research Foundation (Agreement #: 80NSSC22M0060).”
4. Singh A, Santa Maria SR, Gentry DM, Liddell LC, Lera MP, Lee JA.Agent-based model for microbial populations exposed to radiation (AMMPER) simulates yeast growth for deep-space experiments.Gravit Space Res. 2024 Nov 22;12(1):159-76.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 1.82
   
   Funding: “Support for A.S. was provided by the California Space Grant (stipend) and the NASA BPS Space Biology Program (computing costs). Empirical data were generated by S.S.M., L.L., and D.G. as part of the BioSentinel Project, supported by NASA’s Advanced Exploration Systems (AES) Program Office.”
5. Tran MT, Gomez SV, Alenicheva V, Remcho VT.A paper-based assay for the determination of total antioxidant capacity in human serum samples.Biosensors. 2024 Nov 18;14(11):559.Note: This article is part of Section “Nano- and Micro-Technologies in Biosensors” (https://www.mdpi.com/journal/biosensors/sections/nano_micro-technologies_biosensors) and may be obtained online without charge.
   
   Journal Impact Factor: 4.9
   
   Funding: “This work was supported by a NASA Space Technology Graduate Research Opportunity, grant number 80NSSC20K1173.”
6. Tronolone JJ, Mohamed N, Chaftari CP, Sun Y, Mathur T, Jain A.Engineering and evaluating vascularized organotypic spheroids on-chip.Current Protocols. 2024 Nov 21;4(11):e70058.PI: A. JainNote: This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal.
   
   Funding: “Acknowledgments This material is based upon work supported by the US Army Medical Research (USAMRAA) Contract No. HT94252410432; NASA, BARDA, NIH, and USFDA, under Contract No. 80ARC023CA002; NHLBI of NIH under Award Number R01HL157790; NSF CAREER Award number 1944322; and TAMU Office of Innovation Translational Investment Funds to A.J.; and by an American Heart Association Predoctoral Fellowship under Grant No. 906239, a National Science Foundation Graduate Research Fellowship under Grant No. 1650114, and a Texas A&M Biomedical Engineering Department National Excellence Fellowship to J.J.T.”

Other papers of interest:

1. Kadipasaoglu CM, Lee VA, Ong J, Lee AG.The optic nerve in spaceflight: Novel concepts in the pathogenesis of optic disc edema in microgravity.Curr Opin Neurol. 2024 Nov 19. Review. Online ahead of print.Note: From the abstract: “Spaceflight-associated neuro-ocular syndrome (SANS) encompasses a unique constellation of neuro-ocular findings in astronauts, including optic disc edema (ODE), globe flattening, chorioretinal folds, and hyperopic refractive shift. Although there are numerous neuro-ocular findings in SANS, the purpose of this review is to describe the novel, emerging concepts of the pathogenesis for the ODE specifically in SANS.”
2. Costanzo R, Scalia G, Noto M, Marrone S, Ferini G, Maugeri R, Iacopino DG, Nicoletti GF, Umana GE.Microgravity effects on glioma cells: A comprehensive review.Discov Med. 2024 Nov;36(190):2143-51. Review.Note: This article may be obtained online without charge.
3. Du X, Zhang Y, Zhang M, Sun Y.Variations in DNA methylation and the role of regulatory factors in rice (Oryza sativa) response to lunar orbit stressors.Front Plant Sci. 2024 Nov 13;15:1427578Note: From the article: “Japonica rice was selected as the plant material for this investigation. Dry seeds of japonica rice were transported aboard the Chang’e-5 lunar probe, enduring a 23-day spaceflight during which they accumulated a radiation dose of approximately 59.85 mGy. Twenty days later, 100 japonica rice seeds from both the ground control group and the spaceflight group were cultivated for their entire life cycle in an artificial climate chamber at Dalian Maritime University.” This article may be obtained online without charge.
4. Fu Y, Liu H, Liu D, Hu D, Xie B, Liu G, Yi Z, Liu H.A case for supporting human long-term survival on the Moon: “Lunar Palace 365” mission.Acta Astronaut. 2024 Dec 2. Online ahead of print.Note: From the abstract: “The bioregenerative life support system (BLSS) is a critical technology that enables long-term human survival on the Moon and other extraterrestrial bodies. In this study, we conducted a 370-day, high-closure integrated mission (“Lunar Palace 365”) on Earth in an upgraded ground-based BLSS facility named “Lunar Palace 1.” This experiment aimed to develop technologies to maintain and adjust system stability under long-term operational conditions and crew shifts.”
5. Gautam A, Chakraborty N, Dimitrov G, Hoke A, Miller SA, Swift K, Sowe B, Conley C, Kacena MA, Hammamieh R.Microgravity’s effects on miRNA-mRNA regulatory networks in a mouse model of segmental bone defects.PLoS One. 2024;19(12):e0313768.Note: From the introduction: “In the current study, we examined miRNA expression in bone and muscle tissue in response to microgravity, segmental bone defect (SBD) surgery, and its combination. These samples were collected from the RR-4 (Rodent Research 4) mission that was launched on February 19, 2017, on SpaceX CRS-10 (Commercial Resupply Services).” This article may be obtained online without charge.
6. Sano S.Accelerated biological evolution in outer space: Insights from numerical analysis.Acta Astronaut. 2024 Dec;225:907-12Note: From the abstract: “As humanity continues its space exploration, understanding biological evolution in extraterrestrial environments will become crucial. On Earth, organisms have adapted to new environments, and some genetic data indicate positive natural selection. This paper investigates the impact of space environments, such as high radiation and microgravity, which may lead to high mutation rates and positive selection, on biological evolution, using numerical analysis.”
7. Yang Q, Chen L, Zhang M, Wang W, Zhang B, Zhou D, Sun Y.Activation characteristics of Ty3-retrotransposons after spaceflight and genetic stability of insertion sites in rice progeny.Front Plant Sci. 2024 Dec 1;15:1452592.Note: This article is part of Research Topic: “Plant Plasticity and Epigenetics” (https://www.frontiersin.org/research-topics/51673/plant-plasticity-and-epigenetics/overview) and may be obtained online without charge.
8. Arbeille P, Zuj K, Guillon L.Exercise combined with artificial gravity and exercise only countermeasures prevent organ and blood vessel morpholgical changes induced by 55 days HDT [head-down tilt] bedrest.Front Physiol. 2024 Nov 27;15:1482860.Note: Head-down tilt bedrest study. This article is part of Research Topic “Exploring Frontiers: Astroparticle, Space Science and Public Health for Future Crewed Space Missions” (https://www.frontiersin.org/research-topics/63490/exploring-frontiers-astroparticle-space-science-and-public-health-for-future-crewed-space-missions/overview). The Research Topic also includes articles from previous Current Awareness Lists #993 https://doi.org/10.3389/fpubh.2022.862598, #1,027 https://doi.org/10.3389/fspas.2022.949432, #1,049 https://doi.org/10.3389/fspas.2023.1117811, and #1,124 https://doi.org/10.3389/fphys.2024.1486767This article may be obtained online without charge.
9. Strauch L, von der Wiesche M, Noppe A, Mulder E, Rieger I, Aeschbach D, Elmenhorst EM.Simulating microgravity with 60 days of 6 degree head-down tilt bedrest compromises sleep.npj Microgravity. 2024 Dec 5;10:109.Note: Head-down tilt bedrest study. This article may be obtained online without charge.
10. Ge J, Liu F, Nie H, Yue Y, Liu K, Lin H, Li H, Zhang T, Yan H, Xu B, Sun H, Yang J, Si S, Zhou J, Cui Y.Simulated microgravity can promote the apoptosis and change inflammatory state of Kupffer cells.Biomed Environ Sci. 2024 Oct 20;37(10):1117-27.Note: A rotary cell culture system was used in this study. This article may be obtained online without charge.
11. Nie H-Y, Ge J, Liu K-G, Yue Y, Li H, Lin H-G, Zhang T, Yan H-F, Xu B-X, Sun H-W, Yang J-W, Si S-Y, Zhou J-L, Cui Y.Moxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity.Life Sci Space Res. 2024 Nov 29. Online ahead of print.Note: Hindlimb unloading study.
12. Wu Z, Liu H, Yan L, Deng Y, Tian Z, Du Y, Zhao Y, Ma H, Deng Y, Li Y, Wang Z.Imaging of gut bacterial macroscopic changes in simulated microgravity-exposed rats via in vivo metabolic labeling.Anal Chem. 2024 Nov 26.Note: Hindlimb unloading study.
13. Meacci E, Chirco A, Garcia-Gil M.Potential vitamin E signaling mediators in skeletal muscle.Antioxidants (Basel). 2024 Nov 13;13(11):1383. Review.Note: This article is part of Special Issue “Advanced in Antioxidant Signaling Mediators/Effectors in Skeletal Muscle Disorders” (https://www.mdpi.com/journal/antioxidants/special_issues/Antioxidant_Signalling_in_Skeletal_Muscle_Disorders) and may be obtained online without charge.
14. Shenkman BS, Kalashnikov VE, Sharlo KA, Turtikova OV, Bokov RO, Mirzoev TM.Continuous use during disuse: Mechanisms and effects of spontaneous activity of unloaded postural muscle.Int J Mol Sci. 2024 Nov 20;25(22):12462. Review.Note: This article is part of Special Issue “Molecular Insight into Skeletal Muscle Atrophy and Regeneration” (https://www.mdpi.com/journal/ijms/special_issues/3CG7A64KFN) and may be obtained online without charge.
15. Malsagov MY, Mikhalchenko EV, Karandashev IM, Stamov LI.Machine learning methods for modeling the kinetics of combustion in problems of space safety.Acta Astronaut. 2024 Dec;225:656-63.Note: From the abstract: “Combustion is a complex physical and chemical process, which is considered both in the modeling of new propulsion systems with high energy efficiency and sufficient safety, and in the modeling of explosion safety and fire extinguishing problems. Fundamental research of this process is one of the key factors responsible for the safety of current and future spaceflights.”
16. Dey A, Jagadanandan J.Unveiling the realm of AI governance in outer space and its importance in national space policy.Acta Astronaut. 2024 Dec 4. Online ahead of print.Note: From the abstract: “This article explores the notable legal concerns that may arise from the growing utilization of artificial intelligence and machine learning in outer space.”

Astrobiology, space medicine, space biology, microgravity,