NASA Spaceline Current Awareness List #1,107 5 July 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Adkins AM, Colby EM, Boden AF, Gotthold JD, Harris RD, Britten RA, Wellman LL, Sanford LD.Effects of social isolation and galactic cosmic radiation on fine motor skills and behavioral performance.Life Sci Space Res (Amst). 2024 May;41:74-9.PI: L.D. SanfordJournal Impact Factor: 2.9
   
   Funding: “This work was supported by the National Aeronautics and Space Administration [grant number CBS VNSCOR 80NSSC19K1582]. …”
2. Seidler RD, Mao XW, Tays GD, Wang T, Zu Eulenburg P.Effects of spaceflight on the brain.Lancet Neurol. 2024 Jun 27. Review. Online ahead of print.PIs: R.D. Seidler, X.W. MaoJournal Impact Factor: 6.5
   
   Funding: “The authors received funding support from the US National Aeronautics and Space Administration (RDS: 80NSSC21K0813; XWM: NNX15AB41G and 80NSSC18K0310), Loma Linda University Department of Basic Sciences (XWM), US National Institutes of Health (GDT: T32-NS082128), Florida Space Grant Consortium (GDT), University of Florida Department of Applied Physiology and Kinesiology Departmental Fellowship (TW), and the German Space Agency on behalf of the Federal Ministry of Economics and Technology and Energy (PZE: 50WB2027 and 50W2327).”
3. Tavakol DN, Nash TR, Kim Y, Graney PL, Liberman M, Fleischer S, Lock RI, O’Donnell A, Andrews L, Ning D, Yeager K, Harken A, Deoli N, Amundson SA, Garty G, Leong KW, Brenner DJ, Vunjak-Novakovic G.Modeling the effects of protracted cosmic radiation in a human organ-on-chip platform.Adv Sci (Weinh). 2024 Jul 4:e2401415.PI: G. Vunjak-NovakovicNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 14.3
   
   Funding: “The authors gratefully acknowledge funding support by the Translational Research in Space Health (TRISH/NASA) agency (Grants RAD0104 andNNX16A069A to G.V.-N.), National Institutes of Health (Grants EB027062, HL076485, and CA249799 to G.V.N., fellowship 1F31CA275733 to D.N.T.) and National Science Foundation (Fellowship 1644869 to D.N.T., grant ERC 16478 to G.V.N.).”
4. Varma C, Luo E, Bostrom G, Bathini P, Berdnik D, Wyss-Coray T, Zhao T, Dong X, Ervin FR, Beierschmitt A, Palmour RM, Lemere CA.Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets.Alzheimer’s & Dementia. 2024 Jul 1. Online ahead of print.PI: C.A. LemereNote: From the abstract: “Vervets are non-human primates that share high genetic homology with humans and develop amyloid beta (Aβ) pathology with aging. We expand current knowledge by examining Aβ pathology, aging, cognition, and biomarker proteomics.” This article may be obtained online without charge.
   
   Journal Impact Factor: 13
   
   Funding: “Behavioural Science Foundation; National Aeronautics and Space Administration, Grant/Award Number: 80NSSC18K0810.”
5. Gross C, Al-Samir M, Bishop JL, Poulet F, Postberg F, Schubert D.Prospecting in-situ resources for future crewed missions to Mars.Acta Astronautica. 2024 Oct;223:15-24.Note: From the introduction: “Establishing human outposts on the Moon or Mars is seen as an important step in future solar system exploration by many members of the community. In recent years, private companies have joined national and international space agencies in this quest and have made decisive contributions. By 2025, the European Space Agency (ESA) is preparing a mission to demonstrate that water or oxygen production is possible on the lunar surface. In this effort, oxygen is likely to be the first resource produced locally to support crewed missions, contributing to the propellant supply or the life support systems.”
   
   Journal Impact Factor: 3.1
   
   Funding: J.L. Bishop is affiliated with NASA Ames Research Center.

Other papers of interest:

1. King SA, Kutz CJ, Chough NG.Spaceflight environment.Emerg Med Clin North Am. 2024 Aug;42(3):695-709. Review.Note: From the abstract: “Prevention of illness and injury continues to be essential to crew health and safety due to the multitude of challenges in the spaceflight environment. As the expansion and frequency of space travel have increased in the past two decades, so has the spectrum of medical conditions that have flown in space, highlighting the importance of prevention as part of the Aerospace Medicine risk mitigation model.”
2. Lee R, Ong J, Waisberg E, Lee AG.Corneal wound healing in spaceflight: Implications of microgravity-induced molecular signaling modulations for corneal health.Eye (Lond). 2024 Jun 26.Note: This article is a comment.
3. Shahbazi M, Rutter LA, Barker R.Transcriptional response of Arabidopsis thaliana‘s root-tip to spaceflight.Plant Mol Biol. 2024 Jun 27;114(4):79.Note: From the abstract: “Plants are expected to play a critical role in the biological life support systems of crewed spaceflight missions, including in the context of upcoming missions targeting the Moon and Mars. Therefore, understanding the response of plants to spaceflight is essential for improving the selection and engineering of plants and spaceflight conditions.”
4. Jin M, Wang J, Zhou Q, Guo P, Zhang J, Wang Y.Effects of different seat inclination angles on lumbar dynamic response and injury during lunar-earth reentry.Front Bioeng Biotechnol. 2024 Jun 11;12:1395114.Note: This article may be obtained online without charge.
5. Le Roy B, Jouvencel A, Friedl-Werner A, Renel L, Cherchali Y, Osseiran R, Sanz-Arigita E, Cazalets JR, Guillaud E, Altena E.Is sleep affected after microgravity and hypergravity exposure? A pilot study.J Sleep Res. 2024 Jun 25:e14279. Online ahead of print.Note: From the article: “Participants took part in one of three different parabolic flight projects taking place between October 2022 and April 2023. Each participant underwent a health screening to participate in the experiment. Exclusion criteria included pregnancy, hyper- or hypotension, cardiovascular problems, and other health problems that would prohibit them to participate in the flight. Data on age, experience with parabolic flights and dosage of scopolamine taken before the flight were collected from the participants. Participants were asked to refrain from caffeine intake before the parabolic flight, and caffeine was not available to them on the premises before the flight.”
6. Ru M, He J, Bai Y, Zhang K, Shi Q, Gao F, Wang Y, Li B, Shen L.Integration of proteomic and metabolomic data reveals the lipid metabolism disorder in the liver of rats exposed to simulated microgravity.Biomolecules. 2024 Jun 12;14(6):682.Note: This article is part of Special Issue “Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants” (https://www.mdpi.com/journal/biomolecules/special_issues/5JR4HV8X19). The Special Issue also includes articles from previous Current Awareness Lists #1,035 https://doi.org/10.3390/biom13020201 and https://doi.org/10.3390/biom13020189; #1,038 https://doi.org/10.3390/biom13020371; #1,084 https://doi.org/10.3390/biom14010065 #1,095 https://doi.org/10.3390/biom14040446; and #1,098 https://doi.org/10.3390/biom14030327. This article may be obtained online without charge.
7. Sokolovskaya AA, Sergeeva EA, Metelkin AA, Popov MA, Zakharova IA, Morozov SG.The expression of cell cycle cyclins in a human megakaryoblast cell line exposed to simulated microgravity.Int J Mol Sci. 2024 Jun 12;25(12):6484.Note: This article is part of Special Issue “Cellular and Molecular Signaling Meet the Space Environment 3.0” (https://www.mdpi.com/journal/ijms/special_issues/S0P509B1W1). This article may be obtained online without charge.
8. Wu W, Ren J, Han M, Huang B.Influence of gut microbiome on metabolic diseases: A new perspective based on microgravity.J Diabetes Metab Disord. 2024 Jun;23(1):353-64. Review.Note: From the abstract: “A comprehensive literature search was performed using the PubMed database to identify relevant publications pertaining to the interplay between gut microbiome, microgravity, space environment, and metabolic diseases.”
9. Asano Y, Yamamoto N, Hayashi K, Miwa S, Higuchi T, Taniguchi Y, Nojima T, Demura S, Tsuchiya H.Membrane formed around liquid nitrogen-treated bone promotes osteogenesis and revitalization in a rat model.Anticancer Res. 2024 Jul;44(7):2887-97.
10. Liu ANN, Baker JHE, Kyle AH, Minchinton AI.A flexible semi-automated assay for assessing radiation-sensitization and toxicity in the mouse intestine.Anticancer Res. 2024 Jul;44(7):2793-803.Note: From the abstract: “The aim of this study was to develop an enhanced intestinal toxicity assay with three outputs assessing proliferation, villi morphology and DNA damage after irradiation.”
11. Chen Y, Xu W, Chen Y, Gong J, Wu Y, Chen S, He Y, Yu H, Xie L.The effect of acute sleep deprivation on cortisol level: A systematic review and meta-analysis.Endocrine Journal. 2024 May 21;advpub. Online ahead of print.Note: This article may be obtained online without charge.
12. Greco I, Machrafi H, Minetti C, Risaliti C, Bandini A, Cialdai F, Monici M, Iorio CS.Hydrogel formulation for biomimetic fibroblast cell culture: Exploring effects of external stresses and cellular responses.Int J Mol Sci. 2024 May 21;25(11):5600.Note: This article is part of Special Issue “Research on Bio-Scaffold for Tissue Engineering” (https://www.mdpi.com/journal/ijms/special_issues/E3Q9481GKD). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

astrobiology, microgravity, space biology