NASA Spaceline Current Awareness List #1,095 12 April 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Rithidech KN, Peanlikhit T, Honikel L, Li J, Liu J, Karakach T, Zimmerman T, Welsh J.Consumption of apigenin prevents radiation-induced gut dysbiosis in male C57BL/6J mice exposed to silicon ions.Radiat Res. 2024 Apr 1;201(4):317-29.PI: K.N. RithidechJournal Impact Factor: 3.4
   
   Funding: “This research project was supported by NASA Grant #80NSSC19K0435.”
2. Munster DW, Lewandowski BE, Nelson ES, Prabhu RK, Myers JG Jr.Modeling the impact of thoracic pressure on intracranial pressure.npj Microgravity. 2024 Apr 10;10(1):46.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was supported by the NASA Human Research Program.”
3. Cochran JD, Walsh K.Clonal hematopoiesis: The emergent CVD [cardiovascular disease] risk factor.Arterioscler Thromb Vasc Biol. 2024 Mar 27;44(4):768-71.PI: K. WalshNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 8.7
   
   Funding: “This work was supported by the University of Virginia Medical Scientist Training Program T32GM007267 to J.D. Cochran; the National Institutes of Health grants AG073249, HL142650, and HL152174; and NASA (National Aeronautics and Space Administration) grant 80NSSC21K0549 to K. Walsh.”
4. Ghosh LD, Mathur T, Tronolone JJ, Chuong A, Rangel K, Corvigno S, Sood AK, Jain A.Angiogenesis-enabled human ovarian tumor microenvironment-chip evaluates pathophysiology of platelets in microcirculation.Adv Healthc Mater. 2024 Mar 30;304263.PI: A. JainNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 10
   
   Funding: “This material is based upon work supported by the NASA, BARDA, NIH, and USFDA, under Contract No. 80ARC023CA002; NHLBI of NIH under Award Number R01HL157790; NSF CAREER Award number 1944322; and Texas A&M University President’s Excellence in Research Award (X-Grant) to A.J. This work was also supported, in part, by the NIH (P50 CA217685, and R35 CA209904), Ovarian Cancer Research Fund Alliance, the Blanton–Davis Ovarian Cancer Research Program, American Cancer Society Research Professor Award, and the Frank McGraw Memorial Chair in Cancer Research to A.K.S.”
5. Layman AJ, Alsbrook SM, Koturbash IK, McGill MR.Natural products that protect against acetaminophen hepatotoxicity: A call for increased rigor in preclinical studies of dietary supplements.J Diet Suppl. 2024 Apr 1;1-18. Online ahead of print. Review.Journal Impact Factor: 2.5
   
   Funding: “MRM was supported in part by grants from the National Institutes of Health (R01 DK135752-01A1) and Haleon. IKK was supported in part by grants from the National Institutes of Health (R21AT011107) and the National Aeronautics and Space Agency (80NSSC21K0544).”
6. Mason CE, Sierra MA, Feng HJ, Bailey SM.Telomeres and aging: On and off the planet!Biogerontology. 2024 Apr 6;25(2):313-27.PI: C.E. MasonNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 4.5
   
   Funding: “CEM thanks the World Quant Foundation, NASA (NNX14AH50G, NNX17AB26G, 80NSSC22K0254, NNH18ZTT001N-FG2, 80NSSC23K0832), the National Institutes of Health (R01MH117406, P01CA214274 R01CA249054), the LLS (MCL7001-18, LLS 9238-16), and the GI Research Foundation (GIRF). SMB gratefully acknowledges funding from NASA (NNX14AB02G and 80NSSC19K0434, 80NSSC23K0832).”

Other papers of interest:

1. Blottner D, Moriggi M, Trautmann G, Furlan S, Block K, Gutsmann M, Torretta E, Barbacini P, Capitanio D, Rittweger J, Limper U, Volpe P, Gelfi C, Salanova M.Nitrosative stress in astronaut skeletal muscle in spaceflight.Antioxidants. 2024;13(4):432.Note: ISS results. This article is part of Special Issue “Antioxidant Response in Skeletal Muscle” (https://www.mdpi.com/journal/antioxidants/special_issues/639M13R0TW) and may be obtained online without charge.
2. Han X, Qu L, Yu M, Ye L, Shi L, Ye G, Yang J, Wang Y, Fan H, Wang Y, Tan Y, Wang C, Li Q, Lei W, Chen J, Liu Z, Shen Z, Li Y, Hu S.Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity.Signal Transduct Target Ther. 2024 Apr 8;9(1):86.Note: From the article: “In this study, we conducted the first astrobiological study on the China Space Station. We proposed a whole new viewpoint for space microgravity-induced adaptation in the heart by virtue of hPSC-CMs. Microgravity exposure reduces the intake and utilization of thiamine in human cardiomyocytes, further disrupting the TCA cycle and reducing ATP production.” This article may be obtained online without charge.
3. Paladugu P, Ong J, Kumar R, Waisberg E, Zaman N, Kamran SA, Tavakkoli A, Rivolta MC, Nelson N, Yoo T, Douglas VP, Douglas K, Song A, Tso H, Lee AG.Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review.Life Sci Space Res. 2024 Apr 6. Review. Online ahead of print.
4. Post TE, Denney C, Cohen A, Jordan J, Limper U.Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research.Br J Clin Pharmacol. 2024 Mar 31. Review. Online ahead of print.Note: This article may be obtained online without charge.
5. Ruprecht NA, Singhal S, Sens D, Singhal SK.Translating genetic findings to epigenetics: identifying the mechanisms associated with aging after high-radiation exposure on Earth and in space.Front Public Health. 2024 Mar 21;12:1333222.Note: This article may be obtained online without charge.
6. Zhang Y, Zhao L, Sun Y.Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice.npj Microgravity. 2024 Apr 4;10(1):45.Note: From the abstract: “Transcriptome profiles are sensitive to space stressors and serve as valuable indicators of the biological effects during spaceflight. Herein, we transformed the expression profiles into gene interaction patterns by single-sample networks (SSNs) and performed the integrated analysis on the 301 spaceflight and 290 ground control samples, which were obtained from the GeneLab platform.” GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
7. Xu Q, Liang R, Gao J, Fan Y, Dong J, Wang L, Zheng C, Yang J, Ming D.rTMS ameliorates time-varing depression and social behaviors in simulated space complex environment associated with VEGF [vascular endothelial growth factor] signaling.Life Sci Space Res. 2024 Apr 8. Online ahead of print.
8. Bowlby B.Extraterrestrial agriculture: Plant cultivation in space.Biotechniques. 2024 Apr 11. Online ahead of print.Note: This article may be obtained online without charge.
9. Fava M, De Dominicis N, Forte G, Bari M, Leuti A, Maccarrone M.Cellular and molecular effects of microgravity on the immune system: A focus on bioactive lipids.Biomolecules. 2024 Apr 5;14(4):446. Review.Note: This article is part of Special Issue “Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants” (https://www.mdpi.com/journal/biomolecules/special_issues/5JR4HV8X19). The Special Issue also includes articles from previous Current Awareness Lists #1,035 https://doi.org/10.3390/biom13020201 and https://doi.org/10.3390/biom13020189; #1,038 https://doi.org/10.3390/biom13020371; and #1,084 https://doi.org/10.3390/biom14010065. This article may be obtained online without charge.
10. Rabiee S, Zaboli S, Sammak AS, Mohebbi A.Effects of simulated microgravity on rat reproductive system: Potential benefits of vitamin D3 intervention.Reprod Sci. 2024 Apr 10.
11. Reed RP.Replace the linear no-threshold model with a risk-informed targeted approach to radiation protection.Health Phys. 2024 Apr 3. Online ahead of print.
12. Balestra C, Lévêque C, Mrakic-Sposta S, Vezzoli A, Wauthy P, Germonpré P, Tillmans F, Guerrero F, Lafère P.Physiology of deep closed circuit rebreather mixed gas diving: Vascular gas emboli and biological changes during a week-long liveaboard safari.Front Physiol. 2024 Apr 9;15:1395846.Note: This article may be obtained online without charge.
13. Griggs BM, Berthoud L.Development of electrostatic removal system for application in dust removal from Martian spacesuits.Acta Astronaut. 2024 May;218:18-34.Note: From the abstract: “Dust removal from Martian spacesuits whilst on exploration activities is critically important for long-term Martian exploration missions. Martian dust is known to contain harmful particles which must be removed from Martian spacesuits to prevent entry into habitation zones on Mars, and prevent spacesuit wear. In this work, an Electrostatic Removal System was developed which utilised the phenomenon of dielectrophoresis to remove Martian dust from the outer layer of spacesuits.”
14. Vilca Coaquira KM, Rojas Chambilla RA, Tejada Flores J, Tintaya Ramos HO, Quispe Trujillo MM, Quispe Humpiri SA, Calisaya Huacasi ÁG, Pino Vanegas YM, Peña Vicuña GF, Salazar Granara AA, Tacuna Calderon AL, Garcia Bedoya NM, Yang M, Hancco Zirena I.Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia.Front Physiol. 2024 Apr 8;15:1387132.Note: This article may be obtained online without charge.
15. Ehmann B, Barkaszi I, Kollerits E, Kiss AI, Balázs L, Altbäcker A.Cultural differences in the ICE-Group experience: Diaries of French and British antarctic winteroverers.Acta Astronaut. 2024 May;218:282-9.Note: From the abstract: “Cultural differences may influence the psychosocial adaptation to prolonged isolation and confinement in extreme environments. Recent results showed that the temporal pattern of mood changes may also be affected by cultural differences. The aim of the study was to gain deeper insight into the structure and temporal patterns of group-related themes mentioned in the diaries of Antarctic winteroverers in two different stations with different national and organizational backgrounds.”
16. Kulich I, Schmid J, Teplova A, Qi L, Friml J.Rapid translocation of NGR proteins driving polarization of PIN-activating D6 protein kinase during root gravitropism.eLife. 2024 May 5;12:RP91523.

Astrobiology, space biology, space life science,