NASA Spaceline Current Awareness List #1,093 29 March 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. 
   Sengupta P, Muthamilselvi Sivabalan SK, Singh NK, Raman K, Venkateswaran K.Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station.Microbiome. 2024 Mar 23;12:62.PI: K. VenkateswaranNote: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 15.5
   
   Funding: “This research was funded by a 2012 Space Biology NNH12ZTT001N grant nos. 19-12829-26 under Task Order NNN13D111T award to K.V., which also funded post-doctoral fellowship for N.K.S. K.R. acknowledges support from the Science and Engineering Board (SERB) MATRICS Grant MTR/2020/000490, IIT Madras, Centre for Integrative Biology and Systems mEdicine (IBSE) and Robert Bosch Center for Data Science and Artificial Intelligence (RBCDSAI).”
2. Wubshet NH, Cai G, Chen SJ, Sullivan M, Reeves M, Mays D, Harrison M, Varnado P, Yang B, Arreguin-Martinez E, Qu Y, Lin S-S, Duran P, Aguilar C, Giza S, Clements T, Liu AP.Cellular mechanotransduction of human osteoblasts in microgravity.npj Microgravity. 2024 2024/03/21;10(1):35.Note: From the abstract: “Here, we aim to study the mechanotransduction mechanisms by which bone loss occurs in microgravity. Two automated experiments, microfluidic chips capable of measuring single-cell mechanics via aspiration and cell spheroids incubated in pressure-controlled chambers, were each integrated into a CubeLab deployed to the ISS National Laboratory. ” This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “N.H.W. acknowledges support from an NIH supplement (R01 EB030031). We acknowledge support from the Bioinformatics Core of the University of Michigan Medical School’s Biomedical Research Core Facilities (RRID:SCR_019168). A.P.L. acknowledges support from the National Science Foundation (CMMI 1927803) and the Center for the Advancement of Science in Space (GA-2023- 9002). T.C. acknowledges support from the Center for the Advancement of Science in Space and the National Aeronautics and Space Administration.”
3. Samson F, Bhat A, Sayyah Z, Reinsch S, Blaber E.Diacylglycerol kinase is downregulated in the Drosophila seizure mutant during spaceflight.Gravitational and Space Research. 2024 Mar 21;12(1):41-5.Note: From the introduction: “In this study, a computational/bioinformatics analysis of omics data from GeneLab Data System’s GLDS-207 project (Correlated Gene and Protein Expression in Heads from Drosophila Reared in Microgravity) was conducted with the goal of identifying critical targets for promoting longevity.” GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
   
   Journal Impact Factor: 0.4
   
   Funding: S. Reinsch and E. Blaber are affiliated with NASA Ames Research Center.
4. Spencer L, Costine B, Irwin T, Dixit A, Spern C, Diaz A, Lozzi B, Li W, Khodadad C, Smith T, Wheeler R, O’Rourke A.Substrate matters: Ionic silver alters lettuce growth, nutrient uptake, and root microbiome in a hydroponics system.Microorganisms. 2024 Mar 4;12(3):515.Note: “In this study, we investigated the effect of Ag+ on lettuce plant growth in ISS-relevant growth chamber conditions in both the traditional ISS growth medium of arcillite and in a hydroponics setup. The methods of this study were conducted to address the following objective: to determine at what concentration silver-treated water influences the growth, nutrient content, and microbiome of a space crop grown on an arcillite (calcinated clay) substrate or without a substrate (hydroponically).” This article is part of Special Issue “Plant Microbiome and Host Tolerance to Biotic and Abiotic Stresses” (https://www.mdpi.com/journal/microorganisms/special_issues/5N2HZY80FZ) and may be obtained online without charge.
   
   Journal Impact Factor: 4.5
   
   Funding: “This research was made possible by Center Innovation Funding (CIF) from NASA’s Science and Technology Mission Directorate (STMD) to Kennedy Space Center (KSC) Exploration and Research Technology (ER&T) Division.”
5. Kamran SA, Hossain KF, Ong J, Zaman N, Waisberg E, Paladugu P, Lee AG, Tavakkoli A.SANS-CNN: An automated machine learning technique for spaceflight associated neuro-ocular syndrome with astronaut imaging data.npj Microgravity. 2024 Mar 28;10:40.PI: A. TavakkoliNote: From the abstract: “Spaceflight associated neuro-ocular syndrome (SANS) is one of the largest physiologic barriers to spaceflight and requires evaluation and mitigation for future planetary missions. As the spaceflight environment is a clinically limited environment, the purpose of this research is to provide automated, early detection and prognosis of SANS with a machine learning model trained and validated on astronaut SANS optical coherence tomography (OCT) images.” This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “We would like to thank NASA and the NASA Human Research Program for their support of this research and providing the astronaut SANS OCT dataset through the through the NASA Lifetime Surveillance of Astronaut Health for validation of this machine learning model. This research has been presented as an abstract at the 2022 Optica Fall Vision Meeting. The work was funded by NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight. Research reported in this publication was supported in part by the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30 GM145646 and by the National Science Foundation under grant numbers OAC-2201599 and OIA-2148788 and by NASA under grant numbers 80NSSC23M0210 and 80NSSC20K1831.”
6. Soares B, Ong J, Osteicoechea D, Kadipasaoglu CM, Waisberg E, Sarker P, Zaman N, Tavakkoli A, Vizzeri G, Lee AG.Ultrasound biomicroscopy as a novel, potential modality to evaluate anterior segment ophthalmic structures during spaceflight: An analysis of current technology.Diagnostics. 2024 Mar 18;14(6):639. Review.PI: A. TavakkoliNote: This article is part of Special Issue “Editorial Board Members’ Collection Series: Recent Advances in Optical Medical Imaging and Therapy Guidance” (https://www.mdpi.com/journal/diagnostics/special_issues/K92AI4465D) and may be obtained online without charge.
   
   Journal Impact Factor: 3.6
   
   Funding: “This research was funded by NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”
7. Wang Y, Neto OP, Weinrich M, Abbott R, Diaz-Artiles A, Kennedy DM.The effect of inherent and incidental constraints on bimanual force control in simulated Martian gravity.Hum Mov Sci. 2024 Jun;95:103199.PI: A. Diaz-ArtilesNote: Head-up and head-down tilt study.
   
   Journal Impact Factor: 2.1
   
   Funding: “This research effort is supported by the NASA Human Research Program, Grant number 80NSSC20K1499…”

Other papers of interest:

1. Golubkina N, Dzhos E, Bogachuk M, Antoshkina M, Verba O, Zavarykina T, Nechitailo G, Murariu OC, Tallarita AV, Caruso G.Effect of seed spaceflight storage on tomato fruit quality and peel/pulp mineral and antioxidant distribution.Horticulturae. 2024 Mar 18;10(3):289.Note: ISS results. This article is part of Special Issue “Indoor Farming and Artificial Cultivation” (https://www.mdpi.com/journal/horticulturae/special_issues/Indoor_Farming) and may be obtained online without charge.
2. Le Roux E, Zahariev A, Chery I, Schoeller DA, Bourdier P, Maillet A, Thevenot C, Garnotel M, Gauquelin-Koch G, Van Den Berghe L, Blanc S, Simon C, Bergouignan A.Substrate metabolism in male astronauts onboard the International Space Station: The ENERGY study.npj Microgravity. 2024 Mar 27;10:39.Note: ISS results. This article may be obtained online without charge.
3. Dwivedi G, Flaman L, Alaybeyoglu B, Frank EH, Black RM, Fite J, Scherzer C, Barton K, Luyster E, Thomas N, Boland E, Krishnan Y, Hung H-H, Chubinskaya S, Trippel SB, Geishecker E, Rosen V, Önnerfjord P, Cirit M, Grodzinsky AJ.Effects of dexamethasone and IGF-1 on post-traumatic osteoarthritis-like catabolic changes in a human cartilage-bone-synovium microphysiological system in space and ground control tissues on Earth.Front Space Technol. 2024 Mar 14;5:1358412.Note: This article is part of Research Topic “Health Monitoring and Intervention Systems for Space Mission” (https://www.frontiersin.org/research-topics/47419/health-monitoring-and-intervention-systems-for-space-mission/overview) and may be obtained online without charge.
4. Venegas JM.Spaceflight-associated neuro-ocular syndrome: Potential etiologies and connections to the glymphatic system.J Neurophysiol. 2024 Mar 27. Review. Online ahead of print.
5. Peng K-L, Kou IE, Chen H.Space medicine.In: Space Tourism Value Chain. Singapore: Springer Nature Singapore, 2024. p. 115-28.
6. Bärligea A, Hase K, Yoshida M.Simulation of human movement in zero gravity.Sensors (Basel). 2024 Mar 9;24(6):1770.Note: This article is part of Special Issue “Biomechanical Analysis of Motion and Postural Control: Sensor Methods and Data Analytics—Third Edition” (https://www.mdpi.com/journal/sensors/special_issues/85D7K6H518) and may be obtained online without charge.
7. Li J, Liu J, Zhang Y, Qiu H, Zheng J, Xue J, Jin J, Ni F, Zhang C, Chen C, Sun X, Wang H, Zhang D.Effects of paternal ionizing radiation exposure on fertility and offspring’s health.Reprod Med Biol. 2024 Mar 25;23(1):e12567.Note: This article may be obtained online without charge.
8. Bonanni R, Cariati I, Rinaldi AM, Marini M, D’Arcangelo G, Tarantino U, Tancredi V.Trolox and recombinant Irisin as a potential strategy to prevent neuronal damage induced by random positioning machine exposure in differentiated HT22 cells.PLoS One. 2024 Mar 21;19(3):e0300888.Note: This article may be obtained online without charge.
9. Ji Y, Lin J, Liu R, Wang K, Chang M, Gao Z, Liu B, Shen Y, Zhu J, Yao X, Qi L, Sun H.Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3.Inflammopharmacology. 2024 Mar 7.Note: Hindlimb unloading study.
10. Puri C, Dannenberg C, Ucci A, Ponzetti M, Pucci E, Silvestri L, Lau P, Frings-Meuthen P, Heer M, Rucci N, Teti A, Maurizi A.Pre-proenkephalin 1 is downregulated under unloading and is involved in osteoblast biology.Calcif Tissue Int. 2024 Mar 20. Online ahead of print.Note: Hindlimb unloading and head-down tilt bedrest study. This article may be obtained online without charge.
11. Wang W, Zheng X, Wang H, Zuo B, Chen S, Li J.Mechanical unloading promotes osteoclastic differentiation and bone resorption by modulating the MSC secretome to favor inflammation.Cell Transplant. 2024 Mar 19;33:9636897241236584.Note: Hindlimb unloading study. This article may be obtained online without charge.
12. Tsuno Y, Mieda M.Circadian rhythm mechanism in the suprachiasmatic nucleus and its relation to the olfactory system.Front Neural Circuits. 2024 Mar 25;18:1385908. Review.Note: This article is part of Research Topic “Neural Circuit Formation and Sensory Inputs” (https://www.frontiersin.org/research-topics/59579/neural-circuit-formation-and-sensory-inputs/overview) and may be obtained online without charge.
13. Zhang Z, Jing Y, Zhang A, Liu J, Yang H, Lou X, Xu L, Liu M, Zhang Y, Gu J.Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice.npj Microgravity. 2024 Mar 23;10(1):37.Note: Hindlimb unloading study. This article may be obtained online without charge.

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