NASA Spaceline Current Awareness List #1,084 26 January 2023 (Space Life Science Research Results)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

1. Biancotti JC, Espinosa-Jeffrey A.Metabolomic profiling of the secretome from human neural stem cells flown into space.Bioengineering (Basel). 2023 Dec 22;11(1):11.PI: A. Espinosa-JeffreyNote: ISS results. This article is part of Special Issue “Proliferation, Differentiation and Metabolism of Stem Cells in Microgravity Environment” (https://www.mdpi.com/journal/bioengineering/special_issues/D56T7JA60K). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
   
   Journal Impact Factor: 4.6
   
   Funding: “This research was funded by NASA Space Biology Grant number NNX15AB43G. The IDDRC Cell Culture Core is supported by NIH/NICHD grant number U54HD087101-05.”
2. Carpo N, Tran V, Biancotti JC, Cepeda C, Espinosa-Jeffrey A.Spaceflight enhances stress pathways in human neural stem cells.Biomolecules. 2024 Jan 3;14(1):65.PI: A. Espinosa-JeffreyNote: ISS results. This article and the article below (Steinwerth et al.) in the “Other papers of interest” section are part of Special Issue “Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants” (https://www.mdpi.com/journal/biomolecules/special_issues/5JR4HV8X19). The Special Issue also includes articles from previous Current Awareness Lists #1,035 https://doi.org/10.3390/biom13020201 and https://doi.org/10.3390/biom13020189; and #1,038 https://doi.org/10.3390/biom13020371. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.5
   
   Funding: “This research was funded by NASA Space Biology Grant, grant number NNX15AB43G; the Cell Culture and Imaging Core is supported by the NIH (Grant U54HD08710).”
3. Bunchek JM, Hummerick ME, Spencer LE, Romeyn MW, Young M, Morrow RC, Mitchell CA, Douglas GL, Wheeler RM, Massa GD.Pick-and-eat space crop production flight testing on the International Space Station.J Plant Interact. 2024 Jan 18;19(1):2292220.PI: G.D. MassaNote: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.2
   
   Funding: “This research was co-funded by the NASA’s Human Research Program and NASA Space Biology (MTL#1075) through the ILSRA 2015 NRA call.”
4. Land ES, Sheppard J, Doherty CJ, Perera IY.Conserved plant transcriptional responses to microgravity from two consecutive spaceflight experiments.Front Plant Sci. 2023 Jan 8;14:1308713.PIs: C.J. Doherty, I.Y. PereraNote: ISS results. This article and the article directly below are part of Research Topic “Progressing the Future of Space Agriculture” (https://www.frontiersin.org/research-topics/52433/progressing-the-future-of-space-agriculture#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,055 https://doi.org/10.3389/fpls.2023.1194753, #1,069 https://doi.org/10.3389/fpls.2023.1265458, #1,070 https://doi.org/10.3389/fpls.2023.1266199, and #1,079 https://doi.org/10.3389/fpls.2023.1284529. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.6
   
   Funding: “The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was funded by NASA (Grant Nos. NNX10AM72G and NNX15AB07G to IP).” C.J. Doherty reports grant 80NSSC19K0146 funding.
5. Malatesta P, Kyriakidis K, Hada M, Ikeda H, Takahashi A, Saganti PB, Georgakilas AG, Michalopoulos I.Differential gene expression in human fibroblasts simultaneously exposed to ionizing radiation and simulated microgravity.Biomolecules. 2024 Jan 10;14(1):88.PI: M. HadaNote: This article is part of Special Issue “DNA Damage and DNA Repair in Cancer” (https://www.mdpi.com/journal/biomolecules/special_issues/0WN8575637). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.5
   
   Funding: “This research was funded by the MEXT Grant-in-Aid for Scientific Research on Innovative Areas, Japan ‘Living in Space’ (grant no. JP15H05945), Gunma University’s Promotion of Scientific Research, and NASA Space Biology Program (grant no. 80NSSC19K0133). A.G.G. would like to acknowledge funding from project 21GRD02 BIOSPHERE that has received funding from the European Partnership on Metrology, co-financed by the European Union’s Horizon Europe Research and Innovation Programme and by the Participating States, the contribution of the COST Action CA21169 = ‘DYNALIFE’ supported by COST (European Cooperation in Science and Technology).”
6. Marinos G, Hamerich IK, Debray R, Obeng N, Petersen C, Taubenheim J, Zimmermann J, Blackburn D, Samuel BS, Dierking K, Franke A, Laudes M, Waschina S, Schulenburg H, Kaleta C.Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.Microbiol Spectr. 2024 Jan 17:e0114423. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 9.043
   
   Funding: “The authors acknowledge support by the German Research Foundation within the collaborative research center ‘Origin and Function of Metaorganisms,’ CRC1182, sub-project A1 to C.K., K.D., and H.S.; the research unit miTarget (FOR5042) to C.K. and the excellence cluster ‘Precision medicine in chronic inflammation’ (EXC2167) to C.K. and H.S. C.K. moreover acknowledges support by the German Ministry for Education and Research (E:Med iTREAT, support code 01ZX1902A). G.M. received support through a Young Investigator Award by the CRC1182. R.D. received support through a Short-Term Research Grant from the Deutscher Akademischer Austauschdienst (German Academic Exchange Service). The authors also acknowledge funding via NIH grant DP2DK116645, NASA grant 80NSSC22K0250, and JGI/DOE grant CSP-503338 (all to B.S.S.).”
7. Park E, Evans MA, Walsh K.Regulators of clonal hematopoiesis and physiological consequences of this condition.J Cardiovasc Aging. 2024 Jan 1;4(1):3. Review.PI: K. WalshNote: This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “This work was supported by National Heart, Lung, and Blood Institute Grants HL142650 and HL152174, National Institute on Aging Grant AG073249, NASA grant 80NSSC21K0549, and Department of Defense grant CA210887P2.”
8. Gottel NR, Hill MS, Neal MJ, Allard SM, Zengler K, Gilbert JA.Biocontrol in built environments to reduce pathogen exposure and infection risk.The ISME Journal. 2024 Jan 10. Online ahead of print.PI: J.A. GilbertNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 11.0
   
   Funding: “The authors are funded by NSF ENG-EPSRC EFRI ELiS: Developing probiotic interventions to reduce the emergence and persistence of pathogens in built environments (UCSD 2223669) and NASA ROSBIO: Quantifying selection for pathogenicity and antibiotic resistance in bacteria and fungi on the ISS – a Microbial Tracking Study (80NSSC19K1604).”
9. Xu C, Song Y, Sempionatto JR, Solomon SA, Yu Y, Nyein HYY, Tay RY, Li J, Heng W, Min J, Lao A, Hsiai TK, Sumner JA, Gao W.A physicochemical-sensing electronic skin for stress response monitoring.Nat Electron. 2024 Jan 19.PI: W. GaoNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 34.3
   
   Funding: “This work was funded by the Translational Research Institute for Space Health through NASA NNX16AO69A, Office of Naval Research grant nos. N00014-21-1-2483 and N00014-21-1-2845, Army Research Office grant no. W911NF-23-1-0041, National Institutes of Health grant nos. R01HL155815 and R21DK13266, National Science Foundation grant no. 2145802, National Academy of Medicine Catalyst Award and High Impact Pilot Research Award no. T31IP1666 from the Tobacco-Related Disease Research Program and Heritage Medical Research Institute (all to W.G.). T.K.H. acknowledges the support from National Institutes of Health grant nos. T32HL144449 and T32EB027629. C.X. acknowledges support from an Amazon AI4Science Fellowship.”

Other papers of interest:

1. Steinwerth P, Bertrand J, Sandt V, Marchal S, Sahana J, Bollmann M, Schulz H, Kopp S, Grimm D, Wehland M.Structural and molecular changes of human chondrocytes exposed to the rotating wall vessel bioreactor.Biomolecules. 2023 Dec 24;14(1):25.Note: A rotating wall vessel was used in this study. This article and the article above (Carpo et al.) in the “NASA” section are part of Special Issue “Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants” (https://www.mdpi.com/journal/biomolecules/special_issues/5JR4HV8X19). This article may be obtained online without charge.
2. Gimunová M, Paludo AC, Bernaciková M, Bienertova-Vasku J.The effect of space travel on human reproductive health: A systematic review.npj Microgravity. 2024 Jan 18;10:10. Review.Note: This article may be obtained online without charge.
3. Jaster JH, Ong J, Ottaviani G.Visual motion hypersensitivity, from spaceflight to Parkinson’s disease-as the chiasmatic cistern may be impacted by microgravity together with normal terrestrial gravity-opposition physiology in the brain.Exp Brain Res. 2024 Jan 22. Online ahead of print.Note: This article is a letter to the editor.
4. Smith L.Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines.Life Sci Space Res (Amst). 2024 Feb;40:126-34. Review.
5. Cucinotta FA, Pak S.Cancer and circulatory disease risks for the largest solar particle events in the space age.Life Sci Space Res (Amst). 2024 Feb;40:1-7.Note: This article may be obtained online without charge.
6. Dai Y, Yu Y, Nie J, Gu K, Pei H.X-ray-downregulated nucleophosmin induces abnormal polarization by anchoring to G-actin.Life Sci Space Res (Amst). 2024 Feb;40:81-8.Note: From the abstract: “Ionizing radiation poses significant risks to astronauts during deep space exploration. This study investigates the impact of radiation on nucleophosmin (NPM), a protein involved in DNA repair, cell cycle regulation, and proliferation.”
7. Jia L, Tang Y, Tian K, Ai W, Shang W, Wu H.Effects of hypobaria, hyperoxia, and nitrogen form on the growth and nutritional quality of lettuce.Life Sci Space Res (Amst). 2024 Feb;40:44-50.
8. Zaccaria T, de Jonge MI, Domínguez-Andrés J, Netea MG, Beblo-Vranesevic K, Rettberg P.Survival of environment-derived opportunistic bacterial pathogens to Martian conditions: Is there a concern for human missions to Mars?Astrobiology. 2024 Jan 12;24(1):100-13.
9. Giacinto O, Lusini M, Sammartini E, Minati A, Mastroianni C, Nenna A, Pascarella G, Sammartini D, Carassiti M, Miraldi F, Chello M, Pelliccia F.Cardiovascular effects of cosmic radiation and microgravity.J Clin Med. 2024 Jan 17;13(2):520. Review.Note: This article is part of Section “Cardiovascular Medicine” (https://www.mdpi.com/journal/jcm/sections/Cardiovascular_Medicine). This article may be obtained online without charge.
10. Graf J, Schulz H, Wehland M, Corydon TJ, Sahana J, Abdelfattah F, Wuest SL, Egli M, Krüger M, Kraus A, Wise PM, Infanger M, Grimm D.Omics studies of tumor cells under microgravity conditions.Int J Mol Sci. 2024 Jan 11;25(2):926. Review.Note: This article is part of Collection “Feature Papers in Molecular Oncology” (https://www.mdpi.com/journal/ijms/topical_collections/feature_papers_oncology). This article may be obtained online without charge.
11. Melica ME, Cialdai F, La Regina G, Risaliti C, Dafichi T, Peired AJ, Romagnani P, Monici M, Lasagni L.Modeled microgravity unravels the roles of mechanical forces in renal progenitor cell physiology.Stem Cell Res Ther. 2024 Jan 17;15:20.Note: The rotary cell culture system was used in this study. This article may be obtained online without charge.
12. Feng J, Liu L, Yang X, Lu F, Zhang M, Wu X, Sun L.Rat bone responses to hindlimb unloading-reloading: Composition, BMD, and mechanical properties.Acta Astronaut. 2024 Feb;215:689-97.Note: Hindlimb unloading study.
13. Kourtidou-Papadeli C, Vernikos J.Lying in bed is bad for your health. Using gravity therapy accelerates rehabilitation.Life Sci Space Res (Amst). 2024 Feb;40:19-20.
14. Tian Y, Wang Z, Cao S, Liu D, Zhang Y, Chen C, Jiang Z, Ma J, Wang Y.Connective tissue inspired elastomer-based hydrogel for artificial skin via radiation-indued penetrating polymerization.Nat Commun. 2024 Jan 20;15:636.Note: “Robust hydrogels offer a candidate for artificial skin of bionic robots, yet few hydrogels have a comprehensive performance comparable to real human skin. Here, we present a general method to convert traditional elastomers into tough hydrogels via a unique radiation-induced penetrating polymerization method.” This article may be obtained online without charge.
15. Viruez-Soto A, Molano-Franco D, Merino-Luna A, Bairam A, Aliaga-Raduán F, Sanchez L, Arias-Reyes C, Soliz J.The ultrasound-based cardiac output monitoring is a useful tool to define baseline hemodynamic parameters in healthy permanent residents at high altitude: Results of a monocentric pilot study.Front Physiol. 2024 Jan 17;14:1297872.Note: This article may be obtained online without charge.