NASA Spaceline Current Awareness List #1,078 8 December 2023 (Space Life Science Research Results)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

1. Kole JA, Barshi I, Healy AF, Schneider VI.Astronaut candidate, candidate-like, and undergraduate subjects compared on retention and transfer.Aerosp Med Hum Perform 2023 Dec;94(12):902-10.Note: From the abstract: “The present study examined long-term retention and transfer of knowledge and skills, as well as the effect of cognitive load on retention and transfer, using a sample of astronaut candidates and two comparison groups. The first comparison group, recruited from Johnson Space Center, was similar in age, education, and general health to the astronaut candidate group; the second comparison group included university undergraduate students.”
   
   Journal Impact Factor: 0.889
   
   Funding: “This research was supported in part by National Aeronautics and Space Administration Grants NCC2-1310 to the University of Colorado Boulder and NNX17AE07A to the University of Northern Colorado. The authors have no competing interests to declare.”
2. Almand A, Ko SY, Anderson A, Keller RJ, Zero M, Anderson AP, Laws JM, Lehnhardt K, Easter BD.A qualitative investigation of space exploration medical evacuation risks.Aerosp Med Hum Perform 2023 Dec;94(12):875-86.Note: From the abstract: “Exploration beyond low Earth orbit requires innovative solutions to support the crew medically, especially as the opportunity for timely evacuation to Earth diminishes. This includes assessing the risks and benefits that a complicated medical evacuation (MEDEVAC) poses to the injured crewmember, the crew, and the mission. This qualitative study identifies common MEDEVAC risk assessment principles used in spaceflight and other extreme environments to better inform future risk assessment tools and exploration mission concepts.”
   
   Journal Impact Factor: 0.889
   
   Funding: K. Lehnhardt and B.D. Easter are affiliated with NASA Johnson Space Center.
3. Brojakowska A, Jackson CJ, Bisserier M, Khlgatian MK, Jagana V, Eskandari A, Grano C, Blattnig SR, Zhang S, Fish KM, Chepurko V, Chepurko E, Gillespie V, Dai Y, Kumar Rai A, Garikipati VNS, Hadri L, Kishore R, Goukassian DA.Lifetime evaluation of left ventricular structure and function in male ApoE null mice after gamma and space-type radiation exposure.Front Physiol. 2023 Nov 20;14:1292033.PI: D.A. GoukassianNote: This article is part of Research Topic “Emerging Molecular Mechanisms in Cardiovascular Physiology and Pathology” (https://www.frontiersin.org/research-topics/54518/emerging-molecular-mechanisms-in-cardiovascular-physiology-and-pathology#overview) and may be obtained online without charge.
   
   Journal Impact Factor: 4.0
   
   Funding: “This work was funded by NASA Human Research Program Grant No: 80NSSC19K1079 (formerly, 80NSSC18K0921) to D.G. This study was also supported by the NIH/NHLBI 1R01HL158998-01A1 and CMREF (LH), 1K01HL159038-01A1 and 5R25HL146166 (to MB). S.B. was funded by the NASA Human Research Program and C.J. by NASA Langley Cooperative Agreement 80LARC17C0004.”
4. Zeineddine Y, Friedman MA, Buettmann EG, Abraham LB, Hoppock GA, Donahue HJ.Genetic diversity modulates the physical and transcriptomic response of skeletal muscle to simulated microgravity in male mice.npj Microgravity. 2023 Dec 1;9:86.PIs: M.A. Friedman, E.G. Buettmann, H.J. DonahueNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “The RNA sequencing data included in this study was generated at the Genomics Core facility at Virginia Commonwealth University. This work was supported by NASA grant 80NSSC18K1473, the Alice T. and William H. Goodwin Jr. Research Endowment, and the Translational Research Institute for Space Health Postdoctoral Fellowship (NASA Cooperative Agreement NNX16AO69A).”
5. Mandt KE.Increasing diversity on spacecraft mission teams reduces risk.Science. 2023 Dec 8;382(6675):eadk7373. Online ahead of print.Journal Impact Factor: 56.9
   
   Funding: K.E. Mandt is affiliated with NASA Goddard Space Flight Center.
6. Trubl G, Stedman KM, Bywaters KF, Matula EE, Sommers P, Roux S, Merino N, Yin J, Kaelber JT, Avila-Herrera A, Johnson PA, Johnson JC, Borges S, Weber PK, Pett-Ridge J, Boston PJ.Astrovirology: How viruses enhance our understanding of life in the universe.Int J Astrobiol. 2023 Aug;22(4):247-71.Note: From the abstract: “Viruses are the most numerically abundant biological entities on Earth. As ubiquitous replicators of molecular information and agents of community change, viruses have potent effects on the life on Earth, and may play a critical role in human spaceflight, for life-detection missions to other planetary bodies and planetary protection. However, major knowledge gaps constrain our understanding of the Earth’s virosphere: (1) the role viruses play in biogeochemical cycles, (2) the origin(s) of viruses, and (3) the involvement of viruses in the evolution, distribution and persistence of life. As viruses are the only replicators that span all known types of nucleic acids, an expanded experimental and theoretical toolbox built for Earth’s viruses will be pivotal for detecting and understanding life on Earth and beyond.” This article may be obtained online without charge.
   
   Journal Impact Factor: 1.7
   
   Funding: E.E. Matula is affiliated with NASA Johnson Space Center. P.J. Boston is affiliated with NASA Ames Research Center.

Other papers of interest:

1. Caruso J, Patel N, Wellwood J, Bollinger L.Impact of exercise-induced strains and nutrition on bone mineral density in spaceflight and on the ground.Aerosp Med Hum Perform. 2023 Dec;94(12):923-33.Note: From the abstract: “While bisphosphonates exhibited promise as an in-flight bone loss treatment, study results are mixed, and this class of drugs has numerous side-effects. While the role antiresorptive agents play in reducing BMD loss is discussed, this review focuses on exercise-induced strains and nutrition, two in-flight treatments without bisphosphonates’ side-effects.”
2. Frandon J, Soussan J, Vidal V, Nikolov T, Rubino B, Luciani A, Paillet A, Boyer L.Expanding the horizons of interventional radiology: Training analog astronauts for percutaneous drainage in preparation for deep space exploration.Cardiovasc Intervent Radiol. 2023 Dec 7. Online ahead of print.
3. Trudel G, Melkus G, Liu T.The ups and downs of bone-marrow adipose tissue in space.Trends Endocrinol Metab. 2023 Nov 30; S1043-2760(23)00242-4. Online ahead of print.Note: From the abstract: “Knowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.”
4. Waisberg E, Ong J, Lee AG.Anaemia, idiopathic intracranial hypertension (IIH) and spaceflight associated neuro-ocular syndrome (SANS).Eye (Lond). 2023 Dec 2.Note: This article is a comment and may be obtained online without charge.
5. Guo W, Hoque J, Garcia Garcia CJ, Spiller KV, Leinroth AP, Puviindran V, Potnis CK, Gunn KA, Newman H, Ishikawa K, Fujimoto TN, Neill DW, Delahoussaye AM, Williams NT, Kirsch DG, Hilton MJ, Varghese S, Taniguchi CM, Wu C.Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells.Sci Transl Med. 2023 Nov 29;15(724):eabo5217.
6. Langevin B, Singh P, Plett PA, Sampson CH, Masters A, Gibbs A, Faria D, Triesler S, Zodda A, Jackson IL, Orschell CM, Gopalakrishnan M, Pelus LM.Pharmacokinetics and biodistribution of 16,16 dimethyl prostaglandin E2 in non-irradiated and irradiated mice and non-irradiated non-human primates.Radiat Res. 2023 Nov 29. Online ahead of print
7. Zhang P, Abudunaibi M, Zhao Q, Wu Y, Aihaiti G, Wu S, Qi J, Shi L, Xu H.Effect of infliximab on radiation-induced submandibular gland dysfunction in rats.Radiat Res. 2023 Dec 4. Online ahead of print.
8. O’Connor AE, Hatzenbiler DM, Flom LT, Bobadilla A-C, Bruns DR, Schmitt EE.Physiological and morphometric differences in resident moderate-altitude vs. sea-level mice.Aerosp Med Hum Perform. 2023 Dec;94(12):887-93.
9. Pang X, Zhang P, Chen X, Liu W.Ubiquitin-proteasome pathway in skeletal muscle atrophy.Front Physiol. 2023 Nov 17;14:1289537. Review.Note: This article may be obtained online without charge.
10. Zuccarelli L, Baldassarre G, Winnard A, Harris KM, Weber T, Green DA, Petersen LG, Kamine TH, Roberts L, Kim DS, Greaves DK, Arya R, Laws JM, Elias A, Rittweger J, Grassi B, Goswami N.Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: A systematic review.npj Microgravity. 2023 Dec 6;9(1):87. Review.Note: This article may be obtained online without charge.
11. Zhang Y, Xia M, Zhao T, Zhang Q, Li R, Yang L.Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells.Cell Mol Biol (Noisy-le-grand). 2023 Nov 15;69(11):25-9.
12. Britton J, Connolly DM, Hawarden DE, Stevenson AT, Harridge SDR, Green NDC, Pollock RD.Initial investigation of a grating stimulus as a visual endpoint for human centrifuge research.Aerosp Med Hum Perform. 2023 Dec;94(12):894-901.
13. Thomas VA, Kelley AM, Lee A, Fotopoulos T, Boggs J, Campbell J.Preliminary evaluation of an osteopathic manipulative treatment to prevent motion sickness.Aerosp Med Hum Perform. 2023 Dec;94(12):934-8.Note: This article may be obtained online without charge.