NASA Spaceline Current Awareness List #1,151 30 May 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Mampre D, Spaide R, Mason S, Van Baalen M, Gibson CR, Mader TH, Wostyn P, Briggs J, Brown D, Lee AG, Patel N, Tarver W, Brunstetter T.Spaceflight associated neuro-ocular syndrome as a potential variant of venous overload choroidopathy.Aerosp Med Hum Perform. 2025 Jun 1;96(6):496-508. Review.Note: From the abstract: “We reviewed literature using the Medline/PubMed database starting in October 2020. Search terms included ocular circulation, hyperopia, serous chorioretinopathy, pigment epithelial detachment, choroidal folds, choroidal thickening, pachychoroid disease, optic disc edema, venous overload choroidopathy. No date exclusions were placed on the search. Articles were reviewed for relevance. Articles relevant to the pathophysiology of choroidal thickening and choroidal venous overload as it applies to SANS were included.”
   
   Journal Impact Factor: 0.889
   
   Funding: T. Brunstetter is affiliated with NASA Johnson Space Center.
2. Pasetes LN, Rosendahl-Garcia KM, Goel N.Bidirectional predictors between baseline and recovery sleep measures and cardiovascular measures during sleep deprivation and psychological stress.Physiol Rep. 2025 May 22;13(10):e70374.PI: N. GoelNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.2
   
   Funding: “This research was funded by the National Aeronautics and Space Administration (NASA) [grant numbers NNX14AN49G and 80NSSC20K0243 (to N.G.)]. This work was also partially supported by the National Institutes of Health [grant number NIH R01DK117488 (to N.G.)].”
3. Kern C, Bonventre JV, Justin AW, Kashani K, Reynolds E, Siew K, Davis B, Karakoy H, Grzesiak N, Bailey DM.Necrosis as a fundamental driver of loss of resilience and biological decline: What if we could intervene?Oncogene. 2025 May 29. Review.Note: From the abstract: “Necrosis is uncontrolled cell death that marks the irreversible threshold of biological degeneration. Rooted in the Greek nekros (death), it is a pivotal mechanism underlying numerous diseases, including cancer, as well as renal, cardiac, neuronal, and hepatic disorders, and more broadly, the aging process. Despite its profound impact on morbidity and mortality, necrosis remains untreatable and has long been viewed as a chaotic, unavoidable aspect of biology. This review examines the mechanisms of necrosis and outlines its far-reaching impact on health, as revealed by emerging evidence.”
   
   Journal Impact Factor: 6.9
   
   Funding: E. Reynolds: NASA Human Research Program, Microsoft and Translational Research Institute for Space Health Space-H Program.
4. Stolc V, Preto O, Karhanek M, Freund F, Griko Y, Loftus DJ, Ohayon MM.RNA-DNA differences: Mechanisms, oxidative stress, transcriptional fidelity, and health implications.Antioxidants (Basel). 2025 Apr 30;14(5):544. Review.PI: PI: V. StolcNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.3
   
   Funding: “NASA Human Research Program grant SA-24-033 to VS.”
5. Vincenty CS, Yoon G, Rogers K, Naruse M, Trappe S, Trappe TA.Human skeletal muscle-specific hypertrophy with exercise training and aging: A comprehensive review.J Appl Physiol (1985). 2025 May 22. Review.PI: C.S. VincentyNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.3
   
   Funding: “This work and our skeletal muscle imaging research has been supported by grants from the NIH (AG-020532, AG-15833, AG-00831, AG-038576, AG-18409, AG-15486) and NASA (NNJ06HF59G, EC400-NCC9-116, NNJ04HF72G.”
6. Rodriguez A, Barcenilla BB, Hall E, Kundel I, Meyers A, Wyatt S, Shippen D, Kurouski D.Raman spectroscopy as a tool for assessing plant growth in space and on lunar regolith simulants.npj Microgravity. 2025 May 27;11(1):19.PIs: S. Wyatt, D. ShippenNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This study was supported by funds from Texas A&M AgriLife Research, Texas A&M University Governor’s University Research Initiative (GURI) grant program of (12-2016/M1700437), by the National Institutes of Health (R01 GM065383 to D.E.S.), the National Aeronautics and Space Administration (80NSSC19K1481 to S.E.W; 80NSSC23K0302 to D.E.S and S.E.W.) and the NASA Postdoctoral Program at Kennedy Space Center administered by Oak Ridge Associated Universities (to A.M.).”

Other papers of interest:

1. Cahill T, Matveychuk N, Hardiman E, Rosner H, Farrell D, Hardiman G.Sedative agents, synthetic torpor, and long-haul space travel-A systematic review.Life (Basel). 2025 Apr 27;15(5):706. Review.Note: This article may be obtained online without charge.
2. Kutz CJ, Mistry AM, Dukes CH.Expanding ketamine application for treatment of acute suicidality in long-duration spaceflight.Aerosp Med Hum Perform. 2025 Jun 1;96(6):509-19.Note: From the abstract: “This literature review was conducted to collate data on ketamine use for acute suicidality and inform on stability, limitations, and utilization of ketamine within extreme environments.”
3. Yao X, Gan Y, Jiang A, Shen Y.Spacecraft alarm interface color and human performance association.Aerosp Med Hum Perform. 2025 Jun 1;96(6):478-84.Note: From the abstract: “A simulated space station warning interface color experiment was conducted with 80 volunteers possessing normal color vision using a head-down position. The selected 27 red warning colors were evaluated based on response time and performance accuracy metrics.”
4. Kingdon J.3 months transit time to Mars for human missions using SpaceX Starship.Sci Rep. 2025 May 22;15(1):17764.Note: From the abstract: “Historically, spacecraft have followed trajectories that took between six and nine months to reach Mars, using traditional chemical propulsion on roughly Hohmann transfers. It is commonly believed that advances in propulsion technology, such as nuclear thermal or VASIMR, are necessary to reduce that transit time. In this paper, we show the feasibility of transit to Mars using the SpaceX Starship taking 90 days. We outline two trajectories that reduce each transit to between 90 and 104 days each way. These trajectories are within NASA career radiation limits, while 180-day trajectories are not.” This article may be obtained online without charge.
5. Cornacchini J, Berkane Y, Tereshenko V, Camuzard O, Lellouch AG, Lupon E.Application of microgravity experiments in plastic surgery: A literature reviewPlast Reconstr Surg Glob Open. 2025 May;13(5):e6802.Note: This article may be obtained online without charge.
6. Pagano CA, Masini MA, Sabbatini M, Gribaudo G, Manfredi M, Caprì FG, Bonetto V, Magnelli V, Donadelli M, Corino R, Belay MH, Robotti E, Marengo E.Simulated microgravity-induced alterations in PDAC cells: A potential role for Trichostatin A in restoring cellular phenotype.Int J Mol Sci. 2025 May 16;26(10):4758.Note: A random positioning machine was used in this study. This article may be obtained online without charge.
7. Padilla AE, C G, Hovell C, Mares J, Reumers V, Clements T, Rextroat J, Gamble P, Lumpp B, Joddar B.Adoption of microfluidic MEA technology for electrophysiology of 3D neuronal networks exposed to suborbital conditions.npj Microgravity. 2025 May 27;11(1):20.Note: From the abstract: “Studying neuronal cells in space reveals how microgravity affects brain function, gene expression, and cellular processes. This study details the preparation and validation of a 3D neuronal electrophysiology (EPHYS) sensing microfluidic biodevice used during a suborbital space flight.” This article may be obtained online without charge.
8. Sonawane R, Patil S, Rahaman J, Mukherjee D.Effect of microgravity on bone tissue: Mechanisms of osteodegeneration and advanced treatment modalities.Biochem Biophys Res Commun. 2025 May 20;771:152055. Review.
9. Greco A, Verde P, De Nuccio C, Spanu C, Minghetti L, Lucertini M.Hormones and biomarkers in student pilots before and after rehabilitation from airsickness.Aerosp Med Hum Perform. 2025 Jun 1;96(6):461-8.
10. Kanas N.The Earth-disconnect phenomenon as a psychological stressor for Martian crewmembers.Aerosp Med Hum Perform. 2025 Jun 1;96(6):530-2.Note: This article is a commentary.
11. Nelson I.Exploring the influence of Schumann resonance and electromagnetic fields on bioelectricity and human health.Electromagn Biol Med. 2025 May 20:1-11. Review.Note: From the abstract: “This article explores the relationship between electromagnetic fields (EMF) and biological systems, focusing on the influence of extremely low-frequency electromagnetic frequencies (ELF), particularly Schumann’s resonance (SR) at 7.83 hz.”
12. Seltikova E, Haghgoo N, Tatár G, Kelly B, Hughes N, Benas A, Goudarzi S, Valle P, Vanolli M, Grace IO, Kim Antonio Stark K, Mai C, Saini P, Dehghani S, Karbala M, John E, Singh S, Romero Rojas C, Elwertowska A, Anand D, Logeswaran A.LUNEX PROSPER: The next generation’s blueprint towards a sustainable human presence on the Moon.Acta Astronaut. 2025 May 24. Online ahead of print.Note: From the abstract: “The growing international momentum toward establishing a sustained human presence on the Moon raises critical questions about its economy, ethics, and sustainability. The emergence of a lunar economy could be the next step in this exploration momentum and includes the potential for economic activities as part of a planned stay on the lunar surface. This paper combines an evaluation of current trends of the lunar economy with insights from the next generation, and revisits the historical milestones of lunar exploration in order to understand the evolution of key sectors.”
13. Tang H, Chai X, Qin X, Lian YE, Gao Y, Wang H, Guo J, Wang B, Wang Y.The impact of mechanical unloading on the gut microbiota and the mitigating role of butyrate in bone loss.Int Immunopharmacol. 2025 June 26;159:114909.
14. Pineiro-Alonso L, Rubio-Prego I, Lobyntseva A, González-Freire E, Langer R, Alonso MJ.Nanomedicine for targeting brain neurodegeneration: Critical barriers and circadian rhythm considerations.Adv Drug Deliv Rev. 2025 Jul;222:115606. Review.
15. Sorrentino RG, Verdel N, Supej M, Ciuha U, Mekjavic IB.Whole-body vibration transmission during resistance vibration exercise.Front Sports Act Living. 2025 May 6;7:1573571.Note: From the abstract: “Resistive exercise combined with whole-body vibration (WBV) and short-arm human centrifugation is being considered as a countermeasure to mitigate muscle and bone loss in astronauts during prolonged space missions. WBV may provide exercise benefits or adverse effects on organs and the lower back. These effects may result from vibration transmitted throughout the body. The objective of this study was to compare vibration transmission (VT) from the ground to the body during resistance vibration exercise (RVE) comprising squat and calf raise performed on a rotational vibration plate.” This article may be obtained online without charge.
16. Ohara K, Katayama M, Kamachi H, Kume A, Karahara I.Prolonged exposure to centrifugal acceleration increases biomass and alters biomass allocation in Arabidopsis thaliana (L.) Heynh. with no apparent impact on elemental concentration in the shoot system.Life Sci Space Res. 2025 May 29. Online ahead of print.

Astrobiology, space biology, space life science, ISS, microgravity,