NASA Spaceline Current Awareness List #1,126 27 November 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Kremsky I, Pergerson R, Justinen S, Stanbouly S, Willey J, Fuller CA, Takahashi S, Vitaterna MH, Bouxsein M, Mao X.Artificial gravity attenuates the transcriptomic response to spaceflight in the optic nerve and retina.Int J Mol Sci. 2024 Nov 9;25(22):2041.PIs: C.A. Fuller, M.H. Vitaterna, M. Bouxsein, X. MaoNote: ISS results. This article is part of Section “Molecular Pathology, Diagnostics, and Therapeutics” (https://www.mdpi.com/journal/ijms/sections/Pathology_Diagnostics_Therapeutics) and may be obtained online without charge.
   
   Journal Impact Factor: 4.9
   
   Funding: “This research is funded by NASA 80NSSC18K0310, 80NSSC19K0534, 80NSSC20K1501, 80NSSC20K1519; and JAXA 21YT000361, 22YT000101, 23YT000129; NIH T32GM144273.”
2. Poveda L, Dash S, Madrid D, Devane K, Lenchik L, Tooze J, Weaver AA.Thoracolumbar spine muscle size and composition changes in long-duration space missions.Life Sci Space Res. 2024 Nov 16. Online ahead of print.PI: A.A. WeaverNote: ISS results.
   
   Journal Impact Factor: 3.2
   
   Funding: “This work was supported by NASA (Grant No. NNX16AP89G).”
3. Park H, Narayanan SA, Caldwell JT, Behnke BJ, Muller-Delp JM, Delp MD.Effects of aging and exercise training on bone and marrow blood flow and vascular function.Bone. 2024 Nov 17:117335. Online ahead of print.PIs: S.A. Narayanan, M.D. DelpNote: From the abstract: “Aging leads to progressive bone loss, which is associated with impaired bone and marrow perfusion. The purpose of this study was to determine whether chronic exercise training enhances blood flow to the femur at rest and during exercise, and elucidate whether putative changes in training-induced bone perfusion are associated with alterations in the intrinsic vasomotor properties of the femoral principal nutrient artery (PNA) in old age.”
   
   Journal Impact Factor: 3.5
   
   Funding: “This work was supported by NIH grant R15 AG055029 and by National Aeronautics and Space Administration Space Biology grants NNX12AL41G, NNX14AQ57G, and 80NSSC19K1322. …”
4. Stolc V, Karhanek M, Freund F, Griko Y, Loftus DJ, Ohayon MM.Metabolic stress in space: ROS-induced mutations in mice hint at a new path to cancer.Redox Biol. 2024 Dec;78:103398.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 10.7
   
   Funding: “This research was supported by NASA ITA#16274 and the NASA Human Research Program to V.S.”

Other papers of interest:

1. Okamura Y, Gochi K, Ishikawa T, Hayashi T, Fuseya S, Suzuki R, Kanai M, Inoue Y, Murakami Y, Sadaki S, Jeon H, Hayama M, Ishii H, Tsunakawa Y, Ochi H, Sato S, Hamada M, Abe C, Morita H, Okada R, Shiba D, Muratani M, Shinohara M, Akiyama T, Kudo T, Takahashi S.Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel.Sci Rep. 2024 Nov 20;14(1):28774.Note: ISS results. This article may be obtained online without charge.
2. Zhang G, Zhao L, Li Z, Sun Y.Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans.Life Sci Space Res. 2024 Nov 22. Online ahead of print.Note: ISS results. From the abstract: “The space environment presents unique stressors, such as microgravity and space radiation, which can induce molecular and physiological changes in living organisms. To identify key reproducible transcriptomic features and explore potential biological roles in space-flown C. elegans, we integrated transcriptomic data from C. elegans subjected to four spaceflights aboard the International Space Station (ISS) and identified 32 reproducibly differentially expressed genes (DEGs).”
3. Manna OM, Burgio S, Picone D, Carista A, Pitruzzella A, Fucarino A, Bucchieri F.Microgravity and human body: Unraveling the potential role of heat-shock proteins in spaceflight and future space missions.Biology. 2024 Nov 13;13(11):921. Review.Note: This article is part of Special Issue “Experimental Biology 100 Years after the Foundation of the Italian Society: A Celebratory Special Issue” (https://www.mdpi.com/journal/biology/special_issues/N6X1B9C6C4). Additional articles will be forthcoming and may be found in the Special Issue. This article may be obtained online without charge.
4. Tian Y, Zhang Z, Jiang C, Chen D, Liu Z, Wei M, Wang C, Wei K.Stressors affect human motor timing during spaceflight.npj Microgravity. 2024 Nov 21;10:108.Note: From the abstract: “Crewed outer-space missions require adequate motor capacity among astronauts, whose sensorimotor system is disturbed by microgravity. Stressors other than microgravity, e.g., sleep loss, confinement, and high workload, characterize the living experience in space and potentially affect motor performance. However, the evidence of these stressors remains elusive. We recruited twelve taikonauts from the China Space Station to conduct a motor timing task that minimized the effect of microgravity on motor performance.” This article may be obtained online without charge.
5. Doshi DJ, Tamgadge S.Aeronautics in dentistry: Navigating oral health challenges in zero gravity.J Academy Dent Educ. 2024 Nov 21;10:111-7.Note: This article may be obtained online without charge.
6. Loke G, Chandrapala J, Besnard A, Kantono K, Brennan C, Newman L, Low J.Food odor perception and affective response in virtual spacecraft and microgravity body posture (1-G) – Potential ground-based simulations.Food Res Int. 2024 Dec;197(Pt 2):115260.
7. Minoretti P, Fontana JM, Yilmaz Y.Pilots, astronauts, and the aerospace microbiota: A narrative review of occupational impact.Cureus. 2024 Oct 24;16(10):e72268. Review.Note: This article may be obtained online without charge.
8. Amiripour H, Iranbakhsh A, Saadatmand S, Mousavi F, Oraghi Ardebili Z.Exogenous application of melatonin and chitosan mitigate simulated microgravity stress in the Rocket (Eruca sativa L.) plant.Plant Physiol Biochem. 2024 Nov 14;218:109294.Note: A 2D clinostat was used in this study.
9. Khan OM, Gasperini W, Necessary C, Jacobs Z, Perry S, Rexroat J, Nelson K, Gamble P, Clements T, DeLeon M, Howard S, Zavala A, Farach-Carson M, Blaber E, Wu D, Satici A, Uzer G.Development and characterization of a low intensity vibrational system for microgravity studies.npj Microgravity. 2024 Nov 20;10(1):107.Note: From the abstract: “Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor’s design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions.” This article may be obtained online without charge.
10. Tyrina E, Yakubets D, Markina E, Buravkova L.Hippo signaling pathway involvement in osteopotential regulation of murine bone marrow cells under simulated microgravity.Cells. 2024 Nov 19;13(22):1921.Note: A random positioning machine was used in this study. This article may be obtained online without charge.
11. Zaghlol R, Pedersen L, Qamer S, Yoo SGK, Ladin DA, Parvathaneni A, Bergom C, Mitchell JD.Cardiac complications of radiation therapy.Cardiol Clin. 2025 Feb;43(1):129-49. Review.
12. Alevizakos V, Werner A, Schiller LM, von See C, Schiller M.Comparing NIRS and pulse oximetry for cerebral oxygen saturation during hypoxia testing.Med Sci (Basel). 2024 Oct 24;12(4):59.Note: From the abstract: “This study evaluates the suitability of cerebral oximetry using near-infrared spectroscopy (NIRS) compared to traditional pulse oximetry (SpO2) for measuring cerebral oxygen saturation during hypoxia testing, aiming to enhance safety during flight operations and training.” This article may be obtained online without charge.
13. Tikhomirova LN, Medvedeva YS, Lebedeva MA, Gavrilov IY, Revenko SV, Karganov MY, Popov EG, Tarakanov IA.The effects of hindlimb unloading of rats on rheographic parameters of femoral and brachial arteries in situ.Bull Exp Biol Med. 2024 Nov 22.

Astrobiology, Space Medicine, Space Biology, Microgravity,