NASA Spaceline Current Awareness List #1,143 4 April 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Huang P, Piatkowski BT, Cherukuri Y, Asmann YW, Zubair AC.Impact of spaceflight on gene expression in cultured human mesenchymal stem/stromal cells.PLoS One. 2025 Mar 13;20(3):e0315285.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: PI reports previous CASIS/NASA funded spaceflight studies.
2. Buckey JC Jr, Lan M, Lewis LD.Space travel-associated motion sickness and its treatment.Br J Clin Pharmacol. 2025 Apr 4. Review. Online ahead of print.PIs: JC Buckey Jr, M. Lan, L.D. LewisNote: From the abstract: “This review presents the main therapeutics available for space-induced motion sickness, the routes of administration available, and the challenges for administering them in space while minimizing major side effects.”
   
   Journal Impact Factor: 3.1
   
   Funding: “Dr. Buckey, Dr. Lewis, and Mimi Lan received support from NASA grant 80NSSC22K0847, which is focused on developing and studying the nebulized intranasal administration of scopolamine hydrobromide.”
3. Rosenberg MJ, Saway BF, Tarver WJ, Pavela JH, Hall J, Al Kasab S, Porto G, Roberts DR.Prevention of cerebrovascular emergencies in spaceflight: A review and a proposal for enhanced medical screening guidelines.Neurol Clin Pract. 2025 Jun;15(3):e200445. Review.Journal Impact Factor: 3.1
   
   Funding: W.J. Tarver and J.H. Pavela are affiliated with NASA Johnson Space Center.
4. Guerin DJ, Gutierrez B, Zhang B, Tseng KA.Notch is required for neural progenitor proliferation during embryonic eye regrowth.Int J Mol Sci. 2025 Mar 14;26(6):2637.Note: This article is part of Special Issue “Notch Signaling Pathways” (https://www.mdpi.com/journal/ijms/special_issues/8487HZ6F08) and may be obtained online without charge.
   
   Journal Impact Factor: 4.9
   
   Funding: “This study was supported by grants from the National Institute of General Medical Sciences of the National Institutes of Health (GM146672 and GM103440) to K.A.-S.T., and research fellowships from the Nevada NASA Space Grant Consortium (80NSSC20M0043) to D.J.G., and National Science Foundation (IIA1301726 and 1757316 to B.G., and OIA2148788 to B.G. and B.Z.).”
5. Lambacher A, Akiyama K, Lingam N, Shuman D, Santa Maria SR.LEIA: NASA’s first biological mission on the lunar surface since 1972.Acta Astronaut. 2025 Jun;231:148-52.PI: S.R. Santa MariaJournal Impact Factor: 3.1
   
   Funding: “We would like to thank all who have participated and are involved in one way or another in the success of the BioSentinel and LEIA missions. BioSentinel’s development was supported by NASA’s Exploration Systems Development Mission Directorate (ESDMD). Ongoing mission operations are supported by NASA Heliophysics. LEIA is supported by NASA’s Science Mission Directorate (SMD). Part of this material is based upon work supported by NASA Space Biology grants.”
6. Karan S, Opdensteinen P, Ma Y, De Oliveira JFA, Steinmetz NF.A replicon-based COVID-19 vaccine candidate delivered by tobacco mosaic virus-like particles.Vaccine. 2025 Apr 19;53:127063.PI: P. OpdensteinenJournal Impact Factor: 4.5
   
   Funding: “This work was supported in part through grants from the National Institutes of Health (NIH R21 AI161306) and National Science Foundation (NSF CBET-2134535 and NSF DMR-2011924, UC San Diego MSREC). P.O. was supported in part through a TRISH post-doctoral fellowship by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. …”

Other papers of interest:

1. Klein GL, Jupiter DC.Elevated coronary artery calcium scores in astronauts.Aerosp Med Hum Perform. 2025 Apr 1;96(4):356-9.Note: From the abstract: “We analyzed a de-identified database provided by NASA consisting of 52 astronauts who had flown a space mission around two determinations of coronary artery calcium (CAC) scores at 5-yr intervals and bone density determinations in the year prior to and 10 d and 1 yr following a space mission.”
2. Clément G.Space biology.In: Fundamentals of Space Medicine. New York: Springer, 2025. p. 55-104.
3. Kang M-K, Bevington J, Tullman-Ercek D.Evaluation of the Salmonella type 3 secretion system (T3SS) as part of a protein production platform for space biology applications.Front Bioeng Biotechnol. 2025 Apr 1;13:1567596.Note: A high aspect ratio vessel was used in this study to simulate microgravity. This article may be obtained online without charge.
4. Ong J, Sampige R, Lee R, Memon H, Panzo N, Kadipasaoglu CM, Guo Y, Sandhur BS, Soares B, Osteicoechea D, Waisberg E, Suh A, Nguyen T, Masalkhi M, Sarker P, Zaman N, Tavakkoli A, Berdahl J, Chévez-Barrios P, Lee AG.Imaging the anterior segment in spaceflight: Understanding and preserving astronaut ocular health for long-duration missions.J Clin Transl Ophthalmol. 2025 Mar 18;3(1):5.Note: This article is a perspective and may be obtained online without charge.
5. Panzo N, Memon H, Ong J, Suh A, Sampige R, Lee R, Waisberg E, Kadipasaoglu CM, Berdahl J, Chévez-Barrios P, Lee AG.Molecular and biomechanical changes of the cornea and lens in spaceflight.Life Sci Space Res. 2025 May;45:151-7. Review.
6. Schlosser KK, Cinelli I, Waelde T, Luque Álvarez L, Pokorádi G, Pósch K, Whiteley I.Optimize behavioral health and human factors research for deep space missions by classifying analog scenarios and fidelity.Front Space Technol. 2025 Mar 30;6:1391331.Note: This article is part of Research Topic “Innovation in Medical Space Technology” (https://www.frontiersin.org/research-topics/57838/innovation-in-medical-space-technology/overview). The Research Topic also includes articles from previous Current Awareness Lists #1,108 https://doi.org/10.3389/frspt.2024.1391200; #1,119 https://doi.org/10.3389/frspt.2024.1384457 and https://doi.org/10.3389/frspt.2024.1422868; and #1,120 https://doi.org/10.3389/frspt.2024.1456614 and https://doi.org/10.3389/frspt.2024.1457487. This article may be obtained online without charge.
7. Noetzel J, Henry P, Mackie R, Cave K, Stefanson JR, Hale JK, Andres K, Jones H.Simulated hearing loss on speech recognition, flight performance, and workload in aviators.Aerosp Med Hum Perform. 2025 Apr;96(4):269-78.Note: This article may be obtained online without charge.
8. Tan J, Zhou Z, Zheng H, Li Y, Wang H, Yang Q, Tian H, Chen H, Xie J, Li Z, Chen Y.Emerging themes and future directions in space radiation health research: A bibliometric exploration from 2013 to 2022.Radiat Environ Biophys. 2025 Mar 29.Note: This article may be obtained online without charge.
9. Chithramol MK, Shine SR.Human thermoregulation in microgravity environments: Insights from a computational model.Life Sci Space Res. 2025 Aug;46:18-38.
10. MacRobbie M, Patel PB.Evaluating risk for astronaut involvement in in-space manufacturing: Analog field testing and future planetary surface procedures.Wilderness Environ Med. 2025 Mar 29;10806032251322091. Online ahead of print.Note: From the abstract: “A key objective of the NASA Artemis program is to establish a sustained human presence on the Moon, along with its international and commercial partners. NASA aims to establish a lunar economy, increasing the need for infrastructure to support human habitation and facilitate growth. In-space manufacturing (ISM) coupled with in situ resource utilization (ISRU) can reduce launch mass and reduce the dependency on Earth resupply for long-term habitation, enabling rapid expansion. However, the space environment introduces unique challenges compared to Earth, such as the absence of an atmosphere, reduced gravity levels, and high consequences of human-machine interactions given the barrier to evacuating an astronaut injured in a manufacturing accident on the Moon, necessitating new safety standards for ISM processes.” This article may be obtained online without charge.
11. Scatto M, Dolci V, Venturini K, Pini B, Petroni A, Bigliardi B.Additive manufacturing in space food: A bibliometric review.Procedia Comput Sci. 2025;253:2498-507.
12. Hoang HNQ, Ho CNQ, Dang LTT, Phan NLC, Doan CC, Nguyen HTM, Le CPM, Hoang SN, Le LT.The proliferation of Chang liver cells after simulated microgravity induction.Curr Issues Mol Biol. 2025 Feb 27;47(3):164.Note: This article is part of Special Issue “The Contribution and Application of Molecular Biology in the Applied Biosciences-Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition” (https://www.mdpi.com/journal/cimb/special_issues/78R334426C) and may be obtained online without charge.
13. López Garzón NA, Pinzón-Fernández MV, Saavedra J, Nati-Castillo HA, Arias-Intriago M, Salazar-Santoliva C, Izquierdo-Condoy JS.Microgravity and cellular biology: Insights into cellular responses and implications for human health.Int J Mol Sci. 2025 Mar 27;26(7):3058. Review.Note: This article is part of Special Issue “Cellular and Molecular Signaling Meet the Space Environment (3rd Edition)” (https://www.mdpi.com/journal/ijms/special_issues/S0P509B1W1). The Special Issue also includes articles from previous Current Awareness Lists #1,107 https://doi.org/10.3390/ijms25126484, #1,113 https://doi.org/10.3390/ijms25158316, and #1,132 https://genelab.nasa.gov. This article may be obtained online without charge.
14. Alchinova IB, Shoibonov BB, Puchkova AA, Karganov MY.Activation of the complement system and changes in the content of modified lipoproteins in antiorthostatic hypokinesia in humans and mice.Bull Exp Biol Med. 2025 Mar 25.Note: Hindlimb unloading study.
15. Ashworth ET, Ogawa R, Vera DR, Lindholm P.Using ¹³N₂ and PET to track in vivo nitrogen gas kinetics during normobaric conditions.Front Physiol. 2025 Mar 31;16:1556478.Note: From the abstract: “Decompression sickness (DCS) during extravehicular activity in space or after diving is caused by gaseous nitrogen. The pathophysiology is still not fully understood, as mechanisms of dissolved gas uptake and bubble development are challenging to study. We aimed to develop a new method using nitrogen-13 ¹³N₂ gas in vivo using positron emission tomography (PET) under normobaric pressure.” This article may be obtained online without charge.
16. Lisyukov AN, Markelova MI, Gainullin, II, Bekmukhamedova EE, Valiullin VV, Islamov RR.Bioinformatic analysis of the transcriptomes of the spinal cord lumbar enlargement cells of mice under condition of hindlimb unloading and subsequent rehabilitation.Bull Exp Biol Med. 2025 Mar 25.
17. Pan Y, Zhang Q, Li C, Li X, Li S, Wang Y, Wang R, Fan J, Tie Y, Zhao X, Gao Y, Wang Y, Sun X.SIRT5 alleviates apoptosis of vascular endothelial cells under simulated microgravity via desuccinylation of ERO1A.Int J Mol Sci. 2025 Mar 23;26(7):2908.Note: A 2D clinostat was used in this study. This article is part of Section “Molecular Biology” (https://www.mdpi.com/journal/ijms/sections/Molecular_Biology) and may be obtained online without charge.
18. Regner AM, DeLeon M, Gibbons KD, Howard S, Nesbitt DQ, Darghiasi SF, Zavala AG, Lujan TJ, Fitzpatrick CK, Farach-Carson MC, Wu D, Uzer G.Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow.Mechanobiology in Medicine. 2025 Mar;3(1):100097.
19. Zhong D, Li X, Yin Z, Chen P, Li Y, Tian J, Wang L, Liu H, Yin K, Zhu L, Kong L, Chen K, Li Y, Hong C, Wang C.Circ-ITCH promotes the ubiquitination degradation of HOXC10 to facilitate osteogenic differentiation in disuse osteoporosis through stabilizing BRCA1 mRNA via IGF2BP2-mediated m⁶A modification.J Transl Med. 2025 Mar 27;23(1):376.Note: This article may be obtained online without charge.

Astrobiology, space biology, space medicine, microgravity, space station,