NASA Spaceline Current Awareness List #1,120 18 October 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Mozneb M, Arzt M, Mesci P, Martin DMN, Pohlman S, Lawless G, Doraisingam S, Al Neyadi S, Barnawi R, Al Qarni A, Whitson PA, Shoffner J, Stoudemire J, Countryman S, Svendsen CN, Sharma A.Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight.npj Microgravity. 2024 Oct 15;10:97.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “A.S. and C.N.S. are supported by the Board of Governors Regenerative Medicine Institute at Cedars-Sinai and an In-Space Production Award (InSPA) from NASA (NNJ13ZBG001N). We are grateful for support from the American Heart Association Career Development Award 856987 (to A.S). The SOX2-GFP hiPSC line was purchased from Coriell and the Allen Institute for Cell Science. We thank Leidos for their assistance in imaging. We thank NASA, Axiom Space, BioServe Space Technologies, the Center for the Advancement of Science in Space, the International Space Station US National Laboratory, and SpaceX for guidance and support during mission operations. We thank Soshana Svendsen for the in-depth reading of this manuscript. We thank NASA astronaut Kate Rubins for her discussions regarding microgravity cell culture.”
2. Mehta SK, Diak DM, Bustos-Lopez S, Nelman-Gonzalez M, Chen X, Plante I, Stray SJ, Tandon R, Crucian BE.Effect of simulated cosmic radiation on cytomegalovirus reactivation and lytic replication.Int J Mol Sci. 2024 Sep 26;25(19):10337.PIs: S.J. Stray, R. TandonNote: This article is part of Section “Molecular Microbiology” (https://www.mdpi.com/journal/ijms/sections/molecular_microbiology) and may be obtained online without charge.
   
   Journal Impact Factor: 4.9
   
   Funding: “This research was funded by NASA Space Biology Grant Number: 80NSSC19K1603, awarded to Satish K. Mehta and Ritesh Tandon.”
3. Verdonschot JAJ, Fuster JJ, Walsh K, Heymans SRB.The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy.Eur Heart J. 2024 Oct 17. Online ahead of print.PI: K. WalshNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 37.6
   
   Funding: “…K.W. receives funding from the National Institutes of Health (NIH)) grants AG073249, HL142650, and HL152174 and NASA grant 80NSSC21K0549. …”
4. Weissman AJ, Flickinger KL, Wu V, DeMaio R, Jonsson A, Prescott P, Monteleone J, Zurowski E, Guyette FX, Gordon BDH, Mortreux M, Melanson K, Buysse DJ, Empey PE, Callaway CW.Quasi-torpor for long-duration space missions.Front Space Technol. 2024 Oct 10;5:1457487. Review.PIs: K.L. Flickinger, C.W. CallawayNote: This article and two articles below in the “Other” section (Barchetti et al. and Urlings et al.) are part of Research Topic “Innovation in Medical Space Technology” (https://www.frontiersin.org/research-topics/57838/innovation-in-medical-space-technology/overview). The Research Topic also includes articles from previous Current Awareness Lists #1,108 https://doi.org/10.3389/frspt.2024.1391200 and #1,119 https://doi.org/10.3389/frspt.2024.1384457 and https://doi.org/10.3389/frspt.2024.1422868. This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “This study was funded by the Translational Research Institute for Space Health (TRISH) and the National Aeronautics and Space Administration (NASA) under a cooperative agreement (NNX16AO69A). Dr. Mortreux received funding from NASA EPSCoR RI 80NSSC22M0040 for work related to this study.”
5. Grigorev KA, Miller J, Narici L, Costes SV.RadLab: An open science resource for radiation studies relevant to human spaceflight.Life Sci Space Res. 2024 Oct 17. Online ahead of print.Note: From the abstract: “In response to the growing need of the space life sciences community for a publicly available single access point for radiation physics data relevant to human space exploration, an open data repository and analysis platform, RadLab, has been developed. RadLab consists of a database and a user-friendly data retrieval, visualization, and analysis toolkit, including a graphical user interface (GUI) and an application programming interface (API).”
   
   Journal Impact Factor: 2.9
   
   Funding: “We thank the members of the RadLab Working Group and the NASA Open Science Data Repository, who have contributed their data and their expertise to establishing RadLab. OSDR is funded by the NASA Space Biology Program, part of the NASA Biological and Physical Sciences Division within the NASA Science Mission Directorate; RadLab development is funded by the NASA Human Research Program (HRP).”
6. Hilzinger JM, Friedline S, Sivanandan D, Cheng YF, Yamazaki S, Clark DS, Skerker JM, Arkin AP.Acetaminophen production in the edible, filamentous cyanobacterium Arthrospira platensis.Biotechnol Bioeng. 2024 Oct 11. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.5
   
   Funding: “This work was supported by the Center for the Utilization of Biological Engineering in Space (CUBES https://cubes.space), a NASA Space Technology Research Institute (grant number NNX17AJ31G)and by NIH S10 OD018174 Instrumentation Grant.”
7. Jaber JM, Ong J, Waisberg E, Sarker P, Zaman N, Tavakkoli A, Lee AG.NASA’s impact on medical innovation: Breakthrough technologies from space research.Acta Astronaut. 2024 Oct 15. Online ahead of print.PI: A. TavakkoliJournal Impact Factor: 3.1
   
   Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”
8. Cui Z, Sato T, Jackson A, Jayarathna S, Itoh M, Yamani Y.Gaze transition entropy as a measure of attention allocation in a dynamic workspace involving automation.Sci Rep. 2024 Oct 8;14:23405.Note: From the abstract: “This study analyzed eye movement data collected in a controlled a MATB-II task environment using gaze transition entropy analysis. In the study, human subjects performed a compensatory tracking task, a system monitoring task, and a communication task concurrently. The results indicate that both gaze transition entropy and stationary gaze entropy, measures of randomness in eye movements, decrease when the compensatory tracking task required more continuous monitoring. The findings imply that gaze transition entropy reflects attention allocation of operators performing dynamic operational tasks consistently.” This article may be obtained online without charge.
   
   Journal Impact Factor: 3.8
   
   Funding: “This study is based upon work supported by the National Science Foundation under Grant No. 2045523 (PI: Jayarathna), by the Kajima Foundation (PI: Itoh) and by an AMA RSES PO Funding Motification: RS-00047-0-S000002 (PI: Yamani). This work was conducted in support of NASA Space Act Agreement SAA1-34376 (Annex No. 1: Visual Attention Allocation and Trust in Human-Autonomy Teaming) established with Old Dominion University.”
9. Rahmanian S, Slaba TC, George S, Braby LA, Bhattacharya S, Straume T, Maria SRS.Galactic cosmic ray environment predictions for the NASA BioSentinel mission, part 2: Post-mission validation.Life Sci Space Res. 2024 Oct 16.Note: From the introduction: “On November 16, 2022, NASA launched the BioSentinel CubeSat as a secondary payload from the Orion Stage Adapter as part of the Artemis-I mission. The objectives of the BioSentinel mission were to measure the deep space radiation environment using a pixel-based radiation spectrometer referred to as the BioSentinel Pixel Dosimeter (BPD) and correlate those measurements with the in-flight biological response of a model organism – S. cerevisiae yeast cells.”
   
   Journal Impact Factor: 2.9
   
   Funding: “This work is supported by the NASA Langley Research Center contract 80LARC23DA003, the Human Research Program under the Space Operations Mission Directorate (SOMD) at NASA, and the Mars Campaign Office RadWorks activity under the Exploration System Development Mission Directorate (ESDMD) at NASA. The BioSentinel program at NASA Ames Research Center was funded by the NASA ESDMD. The extended spaceflight mission radiation measurements are funded by the Heliophysics Division in NASA’s Science Mission Directorate (SMD).”

Other papers of interest:

1. Tocci D, Ducai T, Stoute CAB, Hopkins G, Sabbir MG, Beheshti A, Albensi BC.Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during spaceflight.Front Immunol. 2024 Sep 30;15:1422864. Review.Note: This article may be obtained online without charge.
2. Chaplia O, Mathyk BA, Nichols-Burns S, Basar M, Halicigil C.Beyond Earth’s bounds: Navigating the frontiers of Assisted Reproductive Technologies (ART) in space.Reprod Biol Endocrinol. 2024 Oct 11;22(1):123. Review.Note: From the abstract: “This review summarizes recent updates and innovations in assisted reproductive technologies (ART) on Earth, while also discussing current challenges and areas for improvement in adapting ART studies to the space environment.” This article may be obtained online without charge.
3. Bhambra R.Planning for life on Mars.Nature. 2024 Oct 14;634(8034):746.Note: From the article’s website: “Rebeca Gonçalves explains how plant food could be grown on the red planet.”
4. Kong X, Qin Y, Pei W, Zhou G.Recent progresses on space life science research in China.Life Sci Space Res. 2024 Oct.15;15:1463784.
5. Maffei ME, Balestrini R, Costantino P, Lanfranco L, Morgante M, Battistelli A, Del Bianco M.The physiology of plants in the context of space exploration.Commun Biol. 2024 Oct 11;7:1311. Review.Note: This article may be obtained online without charge.
6. Skirzewski M, Skirzewski A.Beyond Earth’s shield: The surprising way antioxidants could pave the road to Mars.J Neurochem. 2024 Oct 10. Online ahead of print.Note: This article is an editorial and relates to article by Yun et al. titled “The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: Implications for deep space missions, female crews, and potential antioxidant countermeasures” that appeared in Current Awareness list #1,117 https://doi.org/10.1111/jnc.16225. This article may be obtained online without charge.
7. Barchetti K, Derobertmasure A, Boutouyrie P, Sestili P.Redefining space pharmacology: Bridging knowledge gaps in drug efficacy and safety for deep space missions.Front Space Technol. 2024 Oct 18;5:1456614.Note: This article, the article below (Urlings et al.), and an article above in the “NASA” section (Weissman et al.) are part of Research Topic “Innovation in Medical Space Technology” (https://www.frontiersin.org/research-topics/57838/innovation-in-medical-space-technology/overview). This article may be obtained online without charge.
8. Urlings C, Baselet B, Tabury K, Baatout S.Virtual medical astronaut avatars for future deep space missions.Front Space Technol. 2024 Oct 16;5:1423138.Note: This article, the article above (Barchetti et al.), and an article above in the “NASA” section (Weissman et al.) are part of Research Topic “Innovation in Medical Space Technology” (https://www.frontiersin.org/research-topics/57838/innovation-in-medical-space-technology/overview). This article may be obtained online without charge.
9. Zhang H, Li Y, Zhong G.The Space Omics and Medical Atlas (SOMA): New resource for medical research in deep space.MedComm (2020). 2024 Oct 13;5(10):e780.Note: This article may be obtained online without charge.
10. Altaie S, Alrawi A, Duan X, Alnada Q.Exploring the effects of simulated microgravity on esophageal cancer cells: Insights into morphological, growth behavior, adhesion, and genetic damage.J Biol Phys. 2024 Oct 14. Online ahead of print.Note: From the abstract: “The exploration of microgravity has garnered substantial scholarly attention due to its potential to offer unique insights into the behavior of biological systems. This study presents a preliminary investigation into the effects of simulated microgravity on esophageal cancer cells, examining various aspects such as morphology, growth behavior, adhesion, inhibition rate, and DNA damage. To achieve this, a novel microgravity simulator named ‘Gravity Challenge’ was utilized for its effectiveness in minimizing external influences that could compromise microgravity conditions.”
11. Rashed Nizam QM, Ahmed A, Ahmed I, Sihver L.Monte Carlo calculations of target fragments from helium and carbon ion interactions with water.Z Med Phys. 2024 Oct 10. Online ahead of print.Note: From the abstract: “When high energetic heavy ions interact with any target, short range, high linear energy transfer (LET) target fragments are produced. These target fragments (TFs) can give a significant dose to the healthy tissue during heavy ion cancer therapy, and when cosmic radiation interacts with astronauts. This paper presents Monte Carlo simulations, using the Particle and Heavy Ion Transport code System (PHITS), to characterize target fragments from reactions of helium and carbon ions with water.”

Astrobiology, space biology, space medicine, microgravity,