NASA Spaceline Current Awareness List #1,104 14 June 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Ilangovan H, Kothiyal P, Hoadley KA, Elgart R, Eley G, Eslami P.Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes.npj Microgravity. 2024 Jun 11;10:61.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “The authors would like to thank the NASA Space Radiation Element, with special mention of Dr. Janice Zawaski for supporting the scientific discussions and Dr. Brock J. Shisc, for their input on radiation-related discussions, and the NASA Human Research Program for funding that enabled this research. The authors thank NASA Open Science Data Repository and their ML/AI team led by Dr. Lauren Sanders for data access and collaborations on understanding data quality.”
2. Mathyk BA, Tabetah M, Karim R, Zaksas V, Kim J, Anu RI, Muratani M, Tasoula A, Singh RS, Chen YK, Overbey E, Park J, Cope H, Fazelinia H, Povero D, Borg J, Klotz RV, Yu M, Young SL, Mason CE, Szewczyk N, St Clair RM, Karouia F, Beheshti A.Spaceflight induces changes in gene expression profiles linked to insulin and estrogen.Commun Biol. 2024 Jun 11;7:692.PI: C.E. MasonNote: ISS results. GeneLab is available at https://genelab.nasa.gov. This article is part of “Collection Space Omics and Medical Atlas (SOMA) across orbits” (https://www.nature.com/immersive/d42859-024-00009-8/index.html) and may be obtained online without charge.
   
   Journal Impact Factor: 5.9
   
   Funding: “N.S. was supported by grants from NASA [NSSC22K0250; NSSC22K0278] and acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine. A.B. was supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883). C.E.M. thanks the Scientific Computing Unit (SCU) at WCM, the WorldQuant and GI Research Foundation, NASA (NNX14AH50G, NNX17AB26G, NNH18ZTT001N-FG2, 80NSSC22K0254, 80NSSC23K0832, the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A), the National Institutes of Health (R01MH117406), and the LLS (MCL7001-18, LLS 9238-16, 7029-23). H.C. is supported by the Horizon Center for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1). Graphical abstract (Fig. 1a) Created with BioRender.com.”
3. Cope H, Elsborg J, Demharter S, McDonald JT, Wernecke C, Parthasarathy H, Unadkat H, Chatrathi M, Claudio J, Reinsch S, Avci P, Zwart SR, Smith SM, Heer M, Muratani M, Meydan C, Overbey E, Kim J, Chin CR, Park J, Schisler JC, Mason CE, Szewczyk NJ, Willis CRG, Salam A, Beheshti A.Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.Commun Med (Lond). 2024 Jun 11;4(1):106.PI: C.E. MasonNote: This article is part of Collection “Space Omics and Medical Atlas (SOMA) across orbits” (https://www.nature.com/immersive/d42859-024-00009-8/index.html) and may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “H.C. is supported by the Horizon Center for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1). N.S. was supported by grants from NASA [NSSC22K0250; NSSC22K0278]. A.B. was supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883). C.E.M. thanks the WorldQuant Foundation, the GI Research Foundation, NASA (NNX14AH50G, NNX17AB26G, 80NSSC22K0254, NNH18ZTT001N-FG2), the National Institutes of Health (R01MH117406), and the LLS (MCL7001-18, LLS 9238-16). J.K. thanks MOGAM Science Foundation, Boryung, and the National Research Foundation of Korea (RS-2023-00241586).”
4. Reynolds RJ, Shelhamer M, Antonsen EL, Carpentier WR.Characterizing dehydration in short-term spaceflight using evidence from Project Mercury.npj Microgravity. 2024 Jun 11;10:64.PI: M. ShelhamerNote: From the abstract: “Short-term spaceflight is commonly perceived as posing minimal risk to human health and performance. However, despite their duration, short-term flights potentially induce acute physiological changes that create risk to crews. One such change is dehydration (primarily body water loss) due to a heat-stressed environment. Such loss, if severe and prolonged, can lead to decrements in performance as well as increase the risk of more serious medical conditions. Though the general mechanisms of dehydration are broadly understood, the rate and extent of dehydration in short-term spaceflight has not been characterized. Combining data from the six spaceflights of the US Mercury program with a causal diagram illustrating the mechanisms of dehydration, we fit a path model to estimate the causal effects for all pathways in the causal model.” This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: PI reports funding from NASA grant no. 80NSSC19K0487: Assessment of Otolith Function and Asymmetry as a Corollary to Critical Sensorimotor.
5. Mason CE, Green J, Adamopoulos KI, Afshin EE, Baechle JJ, Basner M, Bailey SM, Bielski L, Borg J, Borg J, Broddrick JT, Burke M, Caicedo A, Castañeda V, Chatterjee S, Chin C, Church G, Costes SV, De Vlaminck I, Desai RI, Dhir R, Diaz JE, Etlin SM, Feinstein Z, Furman D, Garcia-Medina JS, Garrett-Bakelman F, Giacomello S, Gupta A, Hassanin A, Houerbi N, Irby I, Javorsky E, Jirak P, Jones CW, Kamal KY, Kangas BD, Karouia F, Kim J, Kim JH, Kleinman A, Lam T, Lawler JM, Lee JA, Limoli CL, Lucaci A, MacKay M, McDonald JT, Melnick AM, Meydan C, Mieczkowski J, Muratani M, Najjar D, Othman MA, Overbey EG, Paar V, Park J, Paul AM, Perdyan A, Proszynski J, Reynolds RJ, Ronca AE, Rubins K, Ryon KA, Sanders LM, Glowe PS, Shevde Y, Schmidt MA, Scott RT, Shirah B, Sienkiewicz K, Sierra M, Siew K, Theriot CA, Tierney BT, Venkateswaran K, Hirschberg JW, Walsh SB, Walter C, Winer DA, Yu M, Zea L, Mateus J, Beheshti A.A second space age spanning omics, platforms, and medicine across orbits.Nature. 2024 Jun 11. Review. Online ahead of print.PIs: C.E. Mason, M. Basner, S.M. Bailey, J.M. Lawler, C.L. Limoli, L. ZeaNote: GeneLab is available at https://genelab.nasa.gov. This article is a perspective and is part of Collection “Space Omics and Medical Atlas (SOMA) across orbits” (https://www.nature.com/immersive/d42859-024-00009-8/index.html) and may be obtained online without charge.
   
   Journal Impact Factor: 64.8
   
   Funding: “Special thanks to Dr. Jack Miller for assisting with the radiation doses in Figure 2. CEM thanks Igor Tulchinsky and the WorldQuant Foundation, NASA (NNX14AH50G, NNX17AB26G, 80NSSC22K0254, NNH18ZTT001N-FG2, 80NSSC19K0432, NNX13AE45G), the National Institutes of Health (R01MH117406, P01CA214274 R01CA249054), the LLS (MCL7001-18, LLS 9238-16), and the GI Research Foundation. J.K. thanks Boryung and their Global Space Healthcare Initiative and Humans In Space programs. A.B. was supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883). SMB gratefully acknowledges funding from NASA (NNX14AB02G and 80NSSC19K0434). JJB thanks the National Institute of Aging for their ongoing support (5T32AG000266-23). RID and CLL thanks the National Aeronautics and Space Administration (NASA), NASA Johnson Space Center grant TXS0147017 (RID) and NASA NSCOR grant number NNX15AI22G (CLL) for funding this work. V.C. thanks ANID-Subdirección de Capital Humano/Doctorado Nacional/2022- 21220897 and FONDECYT 11190998; Proyecto Centro Basal ANID IMPACT:FB210024. A.P. was supported by the Walczak award funded by NAWA – Polish National Agency for Academic Exchange (Agreement No. BPN/WAL/2022/1/00024/U/00001). S.B.W. and K.S. ACCELERATED acknowledges this work was partially funded by the UK Space Agency through a grant [ST/X000036/1] administered by the Science and Technology Facilities Council (STFC). S.B.W. is supported by Kidney Research UK [RP_017_20190306; ST_001_20221128; TF_007_20191202]. K.S. acknowledges this research was funded in part by the Wellcome Trust [Grant number 110282/Z/15/Z]. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. T.L. acknowledges that portion of his research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004).”
6. Didier K, Sanchez S, Shahi A, Capitini C, Schrage W.Extracellular and intracellular inflammatory response of immune cells to radiation exposure.Physiology. 2024 May 21;39(S1):989.Journal Impact Factor: 8.4
   
   Funding: “TRISH through NASA Cooperative Agreement NNX16AO69A and NIH HL150361.”
7. Plante I, West DW, Weeks J, Risca VI.Simulation of radiation-induced DNA damage and protection by histones using the code RITRACKS.BioTech. 2024 Jun 5;13(2):17.PI: V.I. RiscaNote: This article is part of Section Computational Biology (https://www.mdpi.com/journal/biotech/sections/computational_biology) and may be obtained online without charge.
   
   Journal Impact Factor: 3.7
   
   Funding: “This research was funded by NASA Human Research Program Omnibus, grant number 80NSSC21K0565 (V.I.R.), a Scholar Grant from the Rita Allen Foundation (V.I.R.), a Career Scientist Award from the Irma T. Hirschl/Monique Weill-Caulier Trust, and the Human Health and Performance Contract number NNJ15HK11B (I.P.).”
8. Oliveira JC, Crespo Pereira R, Johnson TS, Loureiro R.Seed priming with Ulva lactuca L. in cultivars grown in Martian and lunar regolith analogues.Gravit Space Res. 2024 Jun 9;12(1):77-93.Note: From the abstract: “As human settlements expand to lunar and Martian bases, optimizing food production in these environments becomes crucial. This study investigates the use of macroalgae, specifically Ulva lactuca L., as an affordable, sustainable approach for seed priming to enhance germination in extraterrestrial soils.” This article may be obtained online without charge.
   
   Journal Impact Factor: 2.5
   
   Funding: “The authors would like to thank NASA (National Aeronautics and Space Administration) for providing the operation support as part of the Space Act Agreement with Winston-Salem State University (KCA-4611).”
9. Hall EA, Whittle RS, Diaz-Artiles A.Ocular perfusion pressure is not reduced in response to lower body negative pressure.npj Microgravity. 2024 Jun 8;10(1):67.PI: A. Diaz-ArtilesNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) Human Research Program (HRP), Grant 80NSSC20K1521.”
10. Kamal KY, Othman MA, Kim J-H, Lawler JM.Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: Proof of concept.npj Microgravity. 2024 Jun 11;10:62.PI: J.M. LawlerNote: This article is part of Collection “Space Omics and Medical Atlas (SOMA) across orbits” (https://www.nature.com/immersive/d42859-024-00009-8/index.html) and may be obtained online without charge.
    
    Journal Impact Factor: 5.1
    
    Funding: “This work was generously supported by grants from NASA (80NSSC19K0432, NNX13AE45G) to J.M.L., the Huffines Institute (J.M.L., K.Y.M.), the School of Education and Human Development (R3 Grant) to J.M.L., and the Texas A&M University Office of the President (T3 Grant) to J.M.L.”
11. Ocampo J, Barker H, Rice KC, Ferraro MJ.Impact of payload shielding on Enterobacter cloacae viability and proteomic profile: Insights from a stratospheric weather balloon flight experiment.Gravit Space Res. 2024 Jun 9;12(1):64-76.PI: K.C. RiceNote: This article may be obtained online without charge.
    
    Journal Impact Factor: 2.5
    
    Funding: “This study has been supported by the Florida Space Grant Consortium (FSGC), funded by the National Aeronautics and Space Administration by Cooperative Agreement number 80NSSC21K0601 (Space Trek Academy), 80NSSC20M0093 (MJF), and NASA grant 80NSSC21K0601 (KCR).”
12. Dinh JV, Salas E.Culture and learning, training, and development.In: The Oxford Handbook of Cross-Cultural Organizational Behavior. New York: Oxford University Press, 2024. p. 110.PI: E. Salas
13. Green W, Kim H, Benson E, Rajulu S.Spacesuit contact with wearer: Analysis and visualization.Acta Astronaut. 2024 Jun 13. Online ahead of print.Note: From the introduction: “This study aimed to identify which poses create increased suit contact and where on the wearer’s body that contact occurs. These body regions were then visualized using a novel tool to aid in the understanding of the suit contact data. In particular, this study is focused on the contact patterns differentiated by pressurizing the suit.”
    
    Journal Impact Factor: 3.5
    
    Funding: S. Rajulu is affiliated with NASA Johnson Space Center.
14. McGlumphy S, Damai A, Salameh L, Corbin GB, Wang Q, Markiewicz J, Mosher JJ, Spitzer N, Quiñones R.Biocompatible antibiotic-coupled nickel-titanium nanoparticles as a potential coating material for biomedical devices.Heliyon. 2024 May 30;10(10):e31434.Note: This article may be obtained online without charge.
    
    Journal Impact Factor: 4.0
    
    Funding: “This work was funded by a National Science Foundation (NSF) (Award # CHE1828358); NASA West Virginia Space Grant Consortium (Training Grant # NNX15AI01H and 80NSSC20M0055); and West Virginia Higher Education Policy Commission under the grant numbers HEPC.dsr.18.7., dsr.20.16 amend. 1.1, and Research Challenge Grant (RCG23-009).”

Other papers of interest:

1. Burles F, Willson M, Townes P, Yang A, Iaria G.Preliminary evidence of high prevalence of cerebral microbleeds in astronauts with spaceflight experience.Front Physiol. 2024 Jun 14;15:1360353.Note: ISS results. This article is part of Research Topic “Space Physiology and Medicine: Reports and Unique Data Obtained on Small Sample Sizes” (https://www.frontiersin.org/research-topics/58257/space-physiology-and-medicine-reports-and-unique-data-obtained-on-small-sample-sizes#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,077https://doi.org/10.3389/fphys.2023.1303938 and https://doi.org/10.3389/fphys.2023.1285802; 1,096 https://doi.org/10.3389/fphys.2024.1369788; and #1,102 https://doi.org/10.3389/fphys.2024.1374309. This article may be obtained online without charge.
2. Masood MT, Wang J-W, Zoumi EA, Jain K, Suh A, Ong J, Waisberg E, Masalkhi M, Lee AG.Impedance threshold device as a countermeasure for spaceflight associated neuro-ocular syndrome (SANS): Mitigating mechanisms in proposed pathophysiology.Life Sci Space Res. 2024 Jun 13. Review. Online ahead of print.
3. Piñal O, Arguelles AMixed reality and digital twins for astronaut training.Acta Astronaut. 2024 June;219:376-91.Note: From the abstract: “Astronaut training is complex due to its specific infrastructure and equipment requirements, which are often costly. Immersive technologies can simulate entire environments, allowing for interactive user experiences. Previous research has confirmed the effectiveness of immersive technologies in training and learning. However, simulations alone are insufficient; participants must also engage with vehicles, machinery, and spacecraft systems to understand their impact on the environment and adjacent objects. This study develops four scenarios within three modules, inspired by NASA and ESA astronaut training programs.”
4. Bannova O, Gulacsi E.Architectural approach for evaluation of radiation shielding integration in space habitats.Acta Astronaut. 2024 Jul;220:27-36.Note: From the abstract: “This paper discusses radiation shielding integration approaches through analysis of recent and current space habitat designs and analogs that offer special considerations to the effects of space radiation on the human body and the means for providing space radiation protection for the crew.”
5. Koshlan NA, Isakova MD, Koshlan IV, Melnikova YV, Beliaeva AG, Shtemberg AS, Shamsutdinova OA, Mukhametzianova EI, Gvaramiya IA, Klots IN.[Dynamics of hematological, biochemical, and cytogenetic changes and neurological manifestations in primates irradiated with high-energy krypton ions.]Aviakosm Ekolog Med. 2024;58(2). Russian.
6. Savinkina AO, Shved DM, Lebedeva SA, Vinokhodova AG, Kuznetsova PG, Gushchin VI.[Individual traits and factors of successful adaptation to a two-week isolation modeling a mission on the Moon].Aviakosm Ekolog Med. 2024;58(2). Russian.Note: From the abstract: “Project Eskiz (Sketch) was designed as a 14-day isolation of 4 male and 2 female subjects in a small chamber including exits on a lunar surface.”
7. Zhuravleva OA, Markin AA, Serova AV, Kuzichkin AV, Zhuravleva TV, Vostrikova LV, Loguinov VI, Smirnova TA.[Metabolic reactions of healthy human organisms in the SIRIUS-21 240-day isolation study].Aviakosm Ekolog Med. 2024;58(2). Russian.
8. Serrano J, Boyd J, Brown IS, Mason C, Smith KR, Karolyi K, Maurya SK, Meshram NN, Serna V, Link GM, Gardell SJ, Kyriazis GA.The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity.Nat Commun. 2024 Jun 8;15(1):4915.Note: This article may be obtained online without charge.
9. Lin YS, Lange D, Baur DM, Foerges A, Chu C, Li C, Elmenhorst EM, Neumaier B, Bauer A, Aeschbach D, Landolt HP, Elmenhorst D.Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A₁ adenosine receptor-dependent manner: A double-blind randomized controlled study with PET-MRI.Sci Rep. 2024 Jun 3;14:12724.Note: This article may be obtained online without charge.
10. Lee JY, Kim JH, Freedman BR, Mooney DJ.Motion-accommodating dual-layer hydrogel dressing to deliver adipose-derived stem cells to wounds.Tissue Eng Regen Med. 2024 Jun 8.

Astrobiology, space biology, microgravity,