SPACELINE Current Awareness List

NASA Spaceline Current Awareness List #1,072 – 27 October 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
October 28, 2023
Filed under , , , ,
NASA Spaceline Current Awareness List #1,072 – 27 October 2023 (Space Life Science Research Results)
Space Biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

  1. Soni P, Edwards H, Anupom T, Rahman M, Lesanpezeshki L, Blawzdziewicz J, Cope H, Gharahdaghi N, Scott D, Toh LS, Williams PM, Etheridge T, Szewczyk N, Willis CRG, Vanapalli SA.Spaceflight induces strength decline in Caenorhabditis elegans.Cells. 2023 Oct 17;12(20):2470.PI: S.A. VanapalliNote: ISS results. This article is part of Special Issue “New Insights into Microgravity and Space Biology” ( The Special Issue also includes articles from previous Current Awareness Lists #1,028; #1,032; #1,041 and; #1,061; and #1,064 This article may be obtained online without charge.

    Journal Impact Factor: 6.0

    Funding: “This work was supported by funding from NASA (Grant # NNX15AL16GG and NNJ15GK01C) and the UK BBSRC (Grant # BB/N015894/1). H.C. is supported by the Horizon Center for Doctoral Training at the University of Nottingham (UKRI grant # EP/S023305/1). NS was supported by grants from NASA (NSSC22K0250; NSSC22K0278) and acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osetopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine.”
  2. El-Khoury BB, Ray KL, Altchuler SI, Reichard JF, Dukes CH.Selective serotonin reuptake inhibitors and other treatment modalities for deep space missions.Aerosp Med Hum Perform. 2023 Nov;94(11):843-51. Review.Note: From the abstract: “As humankind ventures further into the depths of space, planning is already underway for long-duration exploration missions that will test the bounds of human performance. Deep space travel will include added risk related to stressors from the isolated, confined, and extreme environment that lies outside the boundaries of low Earth orbit. Currently, selective serotonin reuptake inhibitors (SSRIs) are considered the standard of care for many mental health diagnoses, including anxiety and depression; however, SSRIs are also associated with several undesired side effects. The utility of nonpharmacological therapies for the management of behavioral health conditions has not yet been fully explored.”

    Journal Impact Factor: 0.889

    Funding: J.F. Reichard and C.H. Dukes are affiliated with NASA Johnson Space Center.
  3. Manon J, Saint-Guillain M, Pletser V, Buckland DM, Vico L, Dobney W, Baatout S, Wain C, Jacobs J, Comein A, Drouet S, Meert J, Casla IS, Chamart C, Vanderdonckt J, Cartiaux O, Cornu O.Adequacy of in-mission training to treat tibial shaft fractures in Mars analogue testing.Sci Rep. 2023 Oct 23;13:18072.Note: This article may be obtained online without charge.

    Journal Impact Factor: 4.6

    Funding: D.M. Buckland is affiliated with NASA Johnson Space Center.
  4. Waisberg E, Ong J, Zaman N, Kamran SA, Sarker P, Tavakkoli A, Lee AG.Head-mounted display cataract surgery: A new frontier with eye tracking and foveated rendering technology.Eye (Lond). 2023 Oct 19.PI: A. TavakkoliNote: This article is a correspondence.

    Journal Impact Factor: 3.9

    Funding: “NASA Grant [80NSSC20K183]: A non-intrusive ocular monitoring framework to model ocular structure and functional changes due to long-term spaceflight.”
  5. Zaman N, Ong J, Waisberg E, Masalkhi M, Lee AG, Tavakkoli A, Zuckerbrod S.Advanced visualization engineering for vision disorders: A clinically focused guide to current technology and future applications.Ann Biomed Eng. 2023 Oct 20. Review.PI: A. TavakkoliNote: This article may be obtained online without charge.

    Journal Impact Factor: 3.8

    Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”
  6. Walsh RFL, Klugman J, Moriarity DP, Titone MK, Ng TH, Goel N, Alloy LB.Reward sensitivity and social rhythms during goal-striving: An ecological momentary assessment investigation of bipolar spectrum disorders.J Affect Disord. 2023 Oct 16;344:510-8.PI: N. GoelJournal Impact Factor: 6.6

    Funding: “This study was supported in part by the National Science Foundation’s Graduate Research Fellowship to Rachel Walsh and by National Institute of Mental Health R01 grants MH077908, MH102310, and MH126911 to Lauren B. Alloy. Namni Goel was supported in part by the National Aeronautics and Space Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 and National Institutes of Health grant R01DK117488.”

Other papers of interest:

  1. Masís Solano M, Bélanger Nzakimuena C, Dumas R, Lesk MR, Costantino S.Ocular rigidity and choroidal thickness changes in response to microgravity: A case study.Am J Ophthalmol Case Rep. 2023 Dec;32:101940.Note: ISS results.
  2. Kovalski E, Salazar L, Levin D, Kamine TH.A 3D-printed portable sterilizer to be used during surgical procedures in spaceflight.Aerosp Med Hum Perform. 2023 Nov;94(11):857-60.Note: From the abstract: “During spaceflight, it is important to consider the mechanisms by which surgeries and medical procedures can be safely and efficiently conducted. Instruments used to carry out these processes need to be sterilized. Thus, we have designed and tested a three-dimensional-printed (3D-printed) portable sterilizer that implements far ultraviolet-C (Far UV-C) light radiation to disinfect bacteria and microorganisms from surgical instruments.”
  3. Narici L, Berger T.Radiation in human space exploration: Detectors and measurements, today and tomorrow.Life Sci Space Res. 2023 Oct 22. Online ahead of print.
  4. Majumder N, Ghosh S.3D biofabrication and space: A “far-fetched dream” or a “forthcoming reality?”Biotechnol Adv. 2023 Dec;69:108273. Review.
  5. Cialdai F, Brown AM, Baumann CW, Angeloni D, Baatout S, Benchoua A, Bereiter-Hahn J, Bottai D, Buchheim JI, Calvaruso M, Carnero-Diaz E, Castiglioni S, Cavalieri D, Ceccarelli G, Choukér A, Ciofani G, Coppola G, Cusella G, Degl’Innocenti A, Desaphy JF, Frippiat JP, Gelinsky M, Genchi G, Grano M, Grimm D, Guignandon A, Hahn C, Hatton J, Herranz R, Hellweg CE, Iorio CS, Karapantsios T, van Loon J, Lulli M, Maier J, Malda J, Mamaca E, Morbidelli L, van Ombergen A, Osterman A, Ovsianikov A, Pampaloni F, Pavezlorie E, Pereda-Campos V, Przybyla C, Puhl C, Rettberg P, Risaliti C, Rizzo AM, Robson-Brown K, Rossi L, Russo G, Salvetti A, Santucci D, Sperl M, Strollo F, Tabury K, Tavella S, Thielemann C, Willaert R, Szewczyk NJ, Monici M.How do gravity alterations affect animal and human systems at a cellular/tissue level?npj Microgravity. 2023 Oct 21;9:84.Note: This article may be obtained online without charge.
  6. Liang R, Wang L, Yang Q, Xu Q, Sun S, Zhou H, Zhao M, Gao J, Zheng C, Yang J, Ming D.Time-course adaptive changes in hippocampal transcriptome and synaptic function induced by simulated microgravity associated with cognition.Front Cell Neurosci. 2023 Oct 5;17:1275771.Note: Hindlimb unloading study. This article is part of Research Topic “Space and Neural Cell: The Impact of Space Environment on Neurological Function and Their Molecular Mechanistic Insights” ( and may be obtained online without charge.
  7. Boyd DD, Scharf MT.Deficient aeronautical decision-making contributions to fatal general aviation accidents.Aerosp Med Hum Perform. 2023 Nov;94(11):807-14.
  8. Wei W, Bai H, Zhang T, Cai S, Zhou Y, Liu M, Zhang Y, Chen Y, Hua J, He J, Ding N, Miao G, Wang J.Regulation of circulating miR-342-3p alleviates the radiation-induced immune system injury.Radiat Res. 2023 Oct 24. Online ahead of print.Note: From the abstract: “Ionizing radiation in space, radiation devices or nuclear disasters are major threats to human health and public security. Expanding countermeasures for dealing with accidental or occupational radiation exposure is crucial for the protection of radiation injuries. Circulating microRNAs (miRNAs) have emerged as promising radiation biomarkers in recent years. However, the origin, distribution and functions of radiosensitive circulating miRNAs remain unclear, which obstructs their clinical applications in the future. In this study, we found that mmu-miR-342-3p (miR-342) in mouse serum presents a stable and significant decrease after X-ray total-body irradiation (TBI). Focusing on this miRNA, we investigated the influences of circulating miR-342 on the radiation-induced injury.”
  9. Li Y, Sun W, Li J, Du R, Xing W, Yuan X, Zhong G, Zhao D, Liu Z, Jin X, Pan J, Li Y, Li Q, Kan G, Han X, Ling S, Sun X, Li Y.HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.Bone Res. 2023 Oct 23;11:53.Note: This article may be obtained online without charge.
  10. Brahmanti RS, Sampurna B, Ibrahim N, Adi NP, Siagian M, Werdhani RA.Obesity and its relation to excessive daytime sleepiness in civilian pilots.Aerosp Med Hum Perform. 2023 Nov;94(11):815-20.
  11. Mecusker ED.Memorial spaceflights and extraterrestrial burial.Cancer Treat Res. 2023;187:341-5.Note: From the abstract: “The human desire to explore our world has led to dramatic shifts in science, technology, and culture. As our knowledge expands so too has our ability to more definitively reach places once thought inhospitable or beyond our grasp. In the early ages of human history, the oceans represented a vast unknown, full of rage and danger suggesting the domain of a tempestuous god or gods. As sailing and navigation developed, our eyes turned to the stars and heavens as the new, final frontier. The emptiness beyond Earth’s atmosphere has only recently become a destination to sate our natural curiosity and, at present, life in outer space remains a dream of science fiction or the lucky few who participate in the scientific study of our universe. For those who feel cheated in being born too late to explore Earth, but also born too early to explore the cosmos, there is a burgeoning space memorials industry that may give some consolation.”


Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻