SPACELINE Current Awareness List

NASA Spaceline Current Awareness List #1,061 4 August 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
August 4, 2023
Filed under , , , , , ,
NASA Spaceline Current Awareness List #1,061 4 August 2023 (Space Life Science Research Results)
Space Biology

Papers deriving from NASA support:

  1. Shavers M, Semones E, Tomi L, Chen J, Straube U, Komiyama T, Shurshakov V, Li C, Rühm W.Space agency-specific standards for crew dose and risk assessment of ionizing radiation exposures for the International Space Station.Z Med Phys. 2023 Jul 26. Online ahead of print.Note: From the abstract: “This manuscript reviews the exposure limits that apply to the ISS crewmembers.” This article may be obtained online without charge.

    Journal Impact Factor: 2

    Funding: M. Shavers and E. Semones are affiliated with NASA Johnson Space Center.
  2. Schneider V, Siegel B, Allen JR.Human health on the Moon and beyond and the results of the Spaceflight for Everybody Symposium.Aerosp Med Hum Perform. 2023 Aug;94(8):634-43.Journal Impact Factor: 0.889

    Funding: “We are indebted to the many talented and knowledgeable NASA people who helped organize and participate in the Spaceflight for Everybody Symposium. This is especially true for the encouragement and participation by NASA leadership. Special thanks also go to the astronauts and many terrestrial research subjects whose biomedical results have become the basis of spaceflight health care and medical information. We acknowledge the financial support by NASA’s HRP leadership and the input and participation by HRP’s talented scientists, engineers, and staff.”
  3. Pantalos GM, Heidel JS, Jain IM, Warner SE, Barefoot TL, Baker RO, Hailey M.Intravenous fluid resuscitation capabilities in simulated reduced gravity.Aerosp Med Hum Perform. 2023 Aug;94(8):596-603.PI: G.M. PantalosNote: From the abstract: “Infusions of water or blood analog (40% glycerol) from a 1 L IV bag were performed using pressure bag augmentation at 0, 150, or 300 mmHg. The solution bag rested on an adjustable mount, configured to different heights to simulate relevant gravitational accelerations (1 G, Martian G, lunar G, and 0 G). The bag emptied through an IV line with a 14- or 20-gauge angiocath into a 3-mmHg venous pressure reservoir. Flow rates were measured using an in-line flow probe. Three determinations were made for each test condition.”

    Journal Impact Factor: 0.889

    Funding: “This research was funded in part by the University of Louisville School of Medicine through the ‘Summer Research Scholars Program.’ This study was also synergized by the Translational Research Institute for Space Health (TRISH) Grant T0110 through the NASA Cooperative Agreement NNX16AO69A.”
  4. Inda-Webb ME, Jimenez M, Liu Q, Phan NV, Ahn J, Steiger C, Wentworth A, Riaz A, Zirtiloglu T, Wong K, Ishida K, Fabian N, Jenkins J, Kuosmanen J, Madani W, McNally R, Lai Y, Hayward A, Mimee M, Nadeau P, Chandrakasan AP, Traverso G, Yazicigil RT, Lu TK.Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ.Nature. 2023 Jul 26.PI: M. JimenezNote: From the abstract: “Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide are key signals and mediators of inflammation. Owing to their highly reactive nature and extremely short lifetime in the body, these molecules are difficult to detect. Here we develop a miniaturized device that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track these molecules in the gastrointestinal tract.”

    Journal Impact Factor: 64.8

    Funding: “This work was supported by Leona M. and Harry B. Helmsley Charitable Trust (3239), Pew Charitable Trusts (to M.E.I.-W.; 00030623) and Catalyst Foundation (to R.T.Y., Q.L. and M.E.I.-W.; Secure Bio-Engineered Sensors for Disease Management, SAP grant no. 55208844). M.J. was supported by the Translational Research Institute of Space Health through Cooperative Agreement NNX16AO69A. G.T. was supported in part by the Department of Mechanical Engineering, MIT and the Karl van Tassel (1925) Career Development Professorship, MIT. Part of this material is based on research sponsored by 711 Human Performance Wing (HPW) and Defense Advanced Research Projects Agency (DARPA) under agreement number FA8650-21-2-7120. The US Government is authorized to reproduce and distribute reprints for governmental purposes notwithstanding any copyright notation thereon.”
  5. Chung DW, Platten KC, Ozawa K, Adili R, Pamir N, Nussdorfer F, St John AE, Ling M, Le J, Harris J, Rhoads NM, Wang Y, Fu X, Chen J, Fazio S, Lindner JR, López JA.Low density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association.Blood. 2023 Jul 28. Online ahead of print.PI: J.R. LindnerNote: From the abstract: “Von Willebrand factor (VWF) mediates primary hemostasis and thrombosis in response to hydrodynamic forces. We previously showed that high shear promoted self-association of VWF into hyperadhesive strands, which can be attenuated by high density lipoprotein (HDL) and apolipoprotein(apo) A-I. Here, we show that low density lipoprotein (LDL) binds VWF under shear and enhances self-association. Vortexing VWF in tubes resulted in its loss from the solution and deposition onto tube surfaces, which was prevented by HDL.”

    Journal Impact Factor: 20.3

    Funding: “This work was supported by grants from the National Institutes of Health R01HL137991 (DWC), R56HL131946 (DWC), R35HL145262 (JAL), R01HL117639 (JAL), R01HL132985 (NP and SF), R01HL136373 (NP), R01HL078610 (JRL), R01HL130046 (JRL), and P51OD011092 (JRL), grant 18-18HCFBP_2-0009 (JRL) from NASA, grant JP201860005 (KO) from Japan Society for the Promotion of Science (Overseas Research Fellowships), Murdock Charitable Trust Grant (XF), and institutional funds from the Bloodworks Northwest.”
  6. Licata JP, Schwab KH, Har-El YE, Gerstenhaber JA, Lelkes PI.Bioreactor technologies for enhanced organoid culture.Int J Mol Sci. 2023 Jul 13;24(14):11427. Review.PI: P.I. LelkesNote: This article is part is Special Issue “State-of-the-Art Materials Science in USA” ( and may be obtained online without charge.

    Journal Impact Factor: 5.6

    Funding: “The recent studies in the Lelkes Lab described in this review were supported by a cooperative Agreement/Grant from NASA (80NSSC18K1480).”
  7. Ong J, Waisberg E, Kamran SA, Paladugu P, Zaman N, Sarker P, Tavakkoli A, Lee AG.Deep learning synthetic angiograms for individuals unable to undergo contrast-guided lazer treatment in aggressive retinopathy of prematurity.Eye (Lond). 2023 Feb 1.PI: A. TavakkoliNote: This article is a correspondence.

    Journal Impact Factor: 3.9

    Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”
  8. Vintila AR, Slade L, Cooke M, Willis CRG, Torregrossa R, Rahman M, Anupom T, Vanapalli SA, Gaffney CJ, Gharahdaghi N, Szabo C, Szewczyk NJ, Whiteman M, Etheridge T.Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans.Proc Natl Acad Sci USA. 2023 Aug 8;120(32):e2216141120. Online ahead of print.PI: S.A. VanapalliNote: This article may be obtained online without charge.

    Journal Impact Factor: 11.1

    Funding: “We would like to acknowledge Caroline Coffey for the technical assistance provided toward the mechanistic experiments of this work. A.R.V., M.W., and T.E. were supported by the US Army Research Office (W911NF-19-1-0235). L.S., M.W., and T.E. were supported by the United Mitochondrial Disease Foundation (PI-19-0985). L.S. was also supported by the University of Exeter Jubilee Scholarship. M.C., N.J.S., and T.E. were supported by the UK Space Agency (ST/R005737/1). N.J.S. and T.E. were supported by BBSRC (BB/N015894/1). S.A.V. was supported by NASA (NNX15AL16G). N.J.S. was supported by grants from NASA [NSSC22K0250; NSSC22K0278] and acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine.”
  9. Ryder JW, Crowell JB, Song HJ, Ewert M.Sweat production during continuous and interval aerobic exercise.Aerosp Med Hum Perform. 2023 Aug;94(8):623-8.Note: From the abstract: “Aerobic exercise within the habitable volume of small spacecraft needed for space exploration beyond low Earth orbit is expected to challenge the capacity of environmental control systems. Moisture control is a primary concern. Crewmembers will contribute moisture to the cabin environment in the form of sweat while exercising. The effects of continuous aerobic exercise for improving and maintaining aerobic capacity is well characterized. Likewise, evidence suggests that high intensity interval exercise for shorter durations is also effective in building and maintaining aerobic capacity.”

    Journal Impact Factor: 0.889

    Funding: J.W. Ryder, H.J. Song, and M. Ewert are affiliated with NASA Johnson Space Center.
  10. Paladugu PS, Ong J, Nelson N, Kamran SA, Waisberg E, Zaman N, Kumar R, Dias RD, Lee AG, Tavakkoli A.Generative adversarial networks in medicine: Important considerations for this emerging innovation in artificial intelligence.Ann Biomed Eng. 2023 Jul 24. Review.PI: A. TavakkoliJournal Impact Factor: 3.8

    Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”

Other papers of interest:

  1. Hart DA.Regulation of bone by mechanical loading, sex hormones, and nerves: Integration of such regulatory complexity and implications for bone loss during spaceflight and post-menopausal osteoporosis.Biomolecules. 2023 Jul 15;13(7):1136. Review.Note: This article is part of Topic “Bone-Related Diseases: From Molecular Mechanisms to Therapy Development” ( This article may be obtained online without charge.
  2. Bizzarri M, Gaudenzi P, Angeloni A.The biomedical challenge associated with the Artemis space program.Acta Astronaut. 2023 Nov;212:14-28.
  3. Waisberg E, Ong J, Masalkhi M, Lee AG.Anemia and Spaceflight Associated Neuro-Ocular Syndrome (SANS).Prehosp Disaster Med. 2023 Jul 31;1-3.
  4. Cheung HC, De Louche C, Komorowski M.Artificial intelligence applications in space medicine.Aerosp Med Hum Perform. 2023 Aug;94(8):610-22. Review.Note: From the abstract: “We conducted a narrative review to discuss existing AI applications that could improve the prevention, recognition, evaluation, and management of the most mission-critical conditions, including psychological and mental health, acute radiation sickness, surgical emergencies, spaceflight-associated neuro-ocular syndrome, infections, and cardiovascular deconditioning.”
  5. Giordano M, Ciriello M, Formisano L, El-Nakhel C, Pannico A, Graziani G, Ritieni A, Kyriacou MC, Rouphael Y, De Pascale S.Iodine-biofortified microgreens as high nutraceutical value component of space mission crew diets and candidate for extraterrestrial cultivation.Plants (Basel). 2023 Jul 12;12(14):2628.Note: This article is part is Special Issue “Effects of the Extraterrestrial Environment on Plants” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
  6. Stahn AC, Bucher D, Zu Eulenburg P, Denise P, Smith N, Pagnini F, White O.Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases.npj Microgravity. 2023 Jul 31;9(1):59. Review.Note: This article may be obtained online without charge.
  7. Miranda S, Marchal S, Cumps L, Dierckx J, Krüger M, Grimm D, Baatout S, Tabury K, Baselet B.A dusty road for astronauts.Biomedicines. 2023 Jul 6;11(7):1921. Review.Note: From the introduction: “This comprehensive review will present a summary of the established physicochemical characteristics of lunar dust and its diverse spectrum of impacts on human health. Furthermore, the existing and upcoming interventions to mitigate the health adversities stemming from lunar dust exposure will be ascertained.” This article is part of Section “Molecular and Translational Medicine” (
  8. Pantalone D.Surgery in the next space missions.Life (Basel). 2023 Jun 29;13(7):1477. Review.Note: This article is part of “Topic Advances in Trauma Pathophysiology” ( and may be obtained online without charge.
  9. Waisberg E, Ong J, Masalkhi M, Lee AG.Space medicine: The next frontier of medical education.Prehosp Disaster Med. 2023 Jul 31;1-3. Online ahead of print.
  10. Murayama T, Oka M, Miyamoto K.Hypergravity conditions inhibit elongation growth and polar auxin transport in epicotyls of etiolated pea seedlings.Biological Sciences in Space. 2023;37:1-11.Note: From the abstract: “Growth and development, and polar auxin transport in epicotyls of etiolated pea (Pisum sativum L. cv Alaska) seedlings grown under hypergravity conditions produced by centrifugation were studied.”
  11. Wang S, Wang J, Zeng X, Wang T, Yu Z, Wei Y, Cai M, Zhuoma D, Chu XY, Chen YZ, Zhao Y.Database of space life investigations and information on spaceflight plant biology.Planta. 2023 Aug 1;258(3):58.
  12. Blue RS, Ong KM, Ray K, Menon A, Mateus J, Auñón-Chancellor S, Shah R, Powers W.Layperson physiological tolerance and operational performance in centrifuge-simulated spaceflight.Aerosp Med Hum Perform. 2023 Aug;94(8):584-95.
  13. Bonanni R, Cariati I, Marini M, Tarantino U, Tancredi V.Microgravity and musculoskeletal health: What strategies should be used for a great challenge?Life (Basel). 2023 Jun 21;13(7):1423. Review.Note: This article is part of Special Issue “Microgravity and Spaceflight: New Insights and Potential Defense Strategies” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
  14. Jang H, Choi SY, Mitchell RJ.Staphylococcus aureus sensitivity to membrane disrupting antibacterials is increased under microgravity.Cells. 2023 Jul 21;12(14):1907.Note: High-aspect ratio vessels (HARVs) were used in this study. This article and the article is part of Special Issue “New Insights into Microgravity and Space Biology” ( The Special Issue also includes articles from previous Current Awareness Lists #1,028; #1,032; and #1,041 and This article may be obtained online without charge.
  15. Keime M, Chomienne L, Goulon C, Sainton P, Lapole T, Casanova R, Bossard M, Nicol C, Martha C, Bolmont B, Hays A, Vercruyssen F, Chavet P, Bringoux L.How about running on Mars? Influence of sensorimotor coherence on running and spatial perception in simulated reduced gravity.Front Physiol. 2023 Jul 31;14:1201253.Note: This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (—volume-ii#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,041; #1,046; #1,051; # 1,053; #1,056; and #1,059 and This article may be obtained online without charge.
  16. Pan C, Zhang Y, Yan J, Zhou Y, Wang S, Liu X, Zhang P, Yang H.Extreme environments and human health: From the immune microenvironments to immune cells.Environ Res. 2023 Jul 30:116800. Review. Online ahead of print.
  17. De Martino M, Daviaud C, Minns HE, Lazarian A, Wacker A, Costa AP, Attarwala N, Chen Q, Choi SW, Rabadàn R, McIntire LBJ, Gartrell RD, Kelly JM, Laiakis EC, Vanpouille-Box C.Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma.Cancer Lett. 2023 Aug;570:216329.
  18. Faddegon BA, Blakely EA, Burigo LN, Censor Y, Dokic I, JN DK, Ortiz R, Ramos-Mendez J, Rucinski A, Schubert KE, Wahl N, Schulte RW.Ionization detail parameters and cluster dose: A mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy.Phys Med Biol. 2023 Jul 24. Online ahead of print.

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Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻